Impairment of visual object-discrimination learning after perirhinal cortex ablation
Impairment of visual object-discrimination learning after perirhinal cortex ablation
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DOI：
10.1037/0735-7044.111.3.467
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发表时间：
1997-06-01
影响因子：
1.9
通讯作者：
Gaffan, D
中科院分区：
文献类型：
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作者：
Buckley, MJ;Gaffan, D
八只食蟹猴术前学习了20个同时出现在触摸屏上的彩色形状对之间的视觉辨别，试验间隔为24小时。3例接受双侧嗅周皮质消融，5例保持对照。消融的猴子在重新获得术前获得的设置严重受损，而术后学习的20个新的歧视没有显着影响。于是，任务变得更加困难。首先，必须从中选择刺激的箔的数量增加到2、4、7，然后是14。第二，提出了更大的40、80和160个问题集。两种操作均显示消融猴出现一些显著但相对轻微的损伤。研究表明，嗅周皮质消融会损害猴子识别单个物体的能力，从而导致视觉物体识别记忆和辨别学习的缺陷。
Eight cynomolgus monkeys learned preoperatively 20 concurrent visual discriminations between pairs of colored shapes presented on a touch screen with 24-hr intertrial intervals. Three then received bilateral perirhinal cortex ablation, and 5 remained controls. The ablated monkeys were severely impaired in reacquiring the preoperatively acquired set, whereas postoperative learning of 20 new discriminations was not significantly affected. The task was then made more difficult. First, the number of foils from which the stimulus had to be selected was increased to 2, 4, 7, and then 14. Second, larger sets of 40, 80, and 160 problems were presented. Both manipulations revealed some significant but relatively mild impairments in the monkeys with ablations. It is suggested that perirhinal cortex ablation impairs the monkey's capacity to identify individual objects, which leads to deficits in both visual-object recognition memory and discrimination learning.