Immunological deficiencies: more frequent than they seem to be.
Immunological deficiencies: more frequent than they seem to be.
复制标题
免疫缺陷：比看起来更常见。
DOI：
10.1016/j.jped.2020.10.009
复制
发表时间：
2021-03
影响因子：
3.3
通讯作者：
Condino Neto, Antonio
中科院分区：
文献类型：
--
作者：
Douglas Paes Barreto, Irma Cecilia;Paes Barreto, Bruno Acatauassu;do Nascimento Cavalcante, Erica Gomes;Condino Neto, Antonio
关键词：
进行了一篇综述文章，讨论了免疫系统缺陷的临床和流行病学特征，这些缺陷与复发性感染过程、自身免疫性疾病、自身炎症性疾病或肿瘤相关或易患，并被分类为先天性免疫缺陷（IEI）和继发性免疫缺陷（SID）。重点放在每个器官和系统的主要体征和症状的分类上，这将作为警告信号，以指导儿科医生调查主要IEI。此外，还确定了由感染（重点是COVID-19）、药物、慢性疾病、代谢和营养失调引发的免疫系统的主要继发性变化。该综述包括过去五年发表的文章，并在MEDLINE平台（PubMed）中识别。感染过程的复发，与病情的严重程度和/或感染因子的异常特征相关，总是与症状发作的年龄范围相关，是疑似诊断的最重要发现。考虑到这种情况，免疫系统疾病应该是普通儿科医生进行的调查的一部分，无论它们是先天性免疫缺陷（原发性免疫缺陷）还是继发性免疫缺陷，以便尽早获得诊断并实施治疗措施，降低这些患者的发病率和死亡率。
A review article was carried out, addressing the clinical and epidemiological characteristics of immune system deficiencies, which are associated with or predispose to recurrent infectious processes, autoimmune diseases, auto inflammatory diseases, or neoplasms, and which are classified as inborn errors of immunity (IEI) and secondary immunodeficiencies (SID). Emphasis was placed on the classification of the main signs and symptoms for each organ and system, which will serve as warning signs, to guide the pediatrician in the investigation of the main IEI. In addition, the main secondary changes in the immune system triggered by infections (with emphasis on COVID-19), drugs, chronic diseases, metabolic and nutritional disorders were identified. This review included articles published in the last five years and that were identified in the MEDLINE platform (PubMed). The recurrence of infectious processes, associated with the severity of the condition and/or unusual profile of the infectious agent, always related to the age range of symptom onset, are the most important findings for suspected diagnosis. Considering this scenario, immunity disorders should be part of the investigation carried out by the general pediatrician, whether they are the innate errors of immunity (primary immunodeficiencies) or secondary immunodeficiencies, so that the diagnosis is attained as early as possible and therapeutic measures are implemented, reducing the morbidity and mortality of these patients.
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DOI：
10.1016/j.jaci.2009.08.040
发表时间：
2010-03
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
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通讯作者：
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影响因子：
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发表时间：
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影响因子：
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作者：
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通讯作者：
Lambadiari, Vaia
影响因子：
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