Development and commissioning of a full-size prototype fixed-beam radiotherapy system with horizontal patient rotation
Development and commissioning of a full-size prototype fixed-beam radiotherapy system with horizontal patient rotation
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DOI：
10.1002/mp.13356
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发表时间：
2019-03-01
期刊：
影响因子：
3.8
通讯作者：
Keall, Paul
中科院分区：
文献类型：
--
作者：
Liu, Paul Zhi Yuan;O'Brien, Ricky;Keall, Paul
目的与传统的旋转式直线加速器相比，固定射束放射治疗系统可以更小、更坚固、更经济。在这项工作中，我们开发并委托了一个原型X射线放射治疗系统，利用固定的垂直辐射束和水平患者旋转。方法原型系统由0度机架固定的Elekta Synergy直线加速器和定制的患者旋转系统(PRS)组成。该系统的设计目的是使患者不能动，并安全地绕着水平轴旋转。直线加速器的联锁和紧急停机连接在一起。开发了定制软件，用于监控系统状态，控制PRS的运动，并修改固定波束配置的治疗计划。安装后，根据AAPM TG-45和TG-142中规定的指南，委托原型系统进行三维(3D)适形治疗，并在必要时对固定光束几何进行修改。结果系统和控制软件在不同的机器状态下进行了测试，并按预期执行了运动、停止和束流选通命令。发现当触发时，直线加速器和PRS的联锁和紧急停机可以正确地停止prs运动以及kV和mV辐射束。对于3D适形治疗，原型系统在几何和剂量精度方面满足所有AAPM TG-45和TG-142规范。在平移和旋转输入值的0.6+/-0.3 mm和0.10度+/-0.07度范围内，旋转矫正器的运动范围。该装置的旋转轴与辐射束轴线重合至小于1 mm。6 MV适形治疗的端到端治疗验证显示，所有区域的计划剂量和交付剂量之间的差异小于2%。结论在这项工作中，我们开发并调试了一套利用固定垂直辐射束和患者水平旋转的放射治疗系统。该系统是无旋转龙门固定梁处理系统的概念验证原型。更小、更具成本效益的固定射束系统可能有助于改善全球获得放射治疗的机会。(C)2018年美国医学物理学家协会
Purpose Compared to conventional linacs with rotating gantries, a fixed-beam radiotherapy system could be smaller, more robust and more cost-effective. In this work, we developed and commissioned a prototype x-ray radiotherapy system utilizing a fixed vertical radiation beam and horizontal patient rotation. Methods The prototype system consists of an Elekta Synergy linac with gantry fixed at 0 degrees and a custom-built patient rotation system (PRS). The PRS was designed to immobilize patients and safely rotate them about the horizontal axis. The interlocks and emergency stops of the linac and PRS were connected. Custom software was developed to monitor the system status, control the motion of the PRS and modify treatment plans for the fixed-beam configuration. Following installation, the prototype system was commissioned for three-dimensional (3D) conformal therapy based on guidelines specified in AAPM TG-45 and TG-142, with modifications for the fixed-beam geometry made where necessary. Results The system and control software was tested in a variety of machine states and executed motion, stop and beam gating commands as expected. Interlocks and emergency stops of the linac and PRS were found to correctly stop PRS motion and both kV and MV radiation beams when triggered. For 3D conformal treatments, the prototype system met all AAPM TG-45 and TG-142 specifications for geometric and dosimetric accuracy. Motion of the PRS was within 0.6 +/- 0.3 mm and 0.10 degrees +/- 0.07 degrees of input values for translation and rotation respectively. The axis of rotation of the PRS was coincident with the radiation beam axis to less than 1 mm. End-to-end treatment verification for 6 MV conformal treatments showed less than 2% difference between planned and delivered dose for all fields. Conclusion In this work, we have developed and commissioned a radiotherapy system that utilizes a fixed vertical radiation beam and horizontal patient rotation. This system is a proof-of-concept prototype for a fixed-beam treatment system without a rotating gantry. Fixed-beam systems that are smaller and more cost-effective could help in improving global access to radiotherapy. (c) 2018 American Association of Physicists in Medicine