Polygonum multiflorum extracts improve cognitive performance in senescence accelerated mice
Polygonum multiflorum extracts improve cognitive performance in senescence accelerated mice
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DOI：
10.1142/s0192415x03000862
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发表时间：
2003-01-01
影响因子：
5.7
通讯作者：
Chang, HC
中科院分区：
文献类型：
--
作者：
Chan, YC;Wang, MF;Chang, HC
本研究旨在探讨何首乌的抗氧化作用。对1月龄和7月龄雄性快速衰老小鼠（SAMP 8）的学习记忆能力的影响。实验分为酪蛋白组（对照组）和酪蛋白饲料添加PM提取物组。采用主动回避实验测定小鼠学习记忆能力，同时测定脑海绵变性程度、脑组织脂褐素、丙二醛和总巯基含量，评价脑组织变性程度和氧化状态。小鼠主动回避实验结果表明，灌胃给药组小鼠的学习记忆能力明显优于对照组。在两个年龄组中，PM组小鼠的海绵变性和脂褐素和丙二醛浓度均显著低于对照组，而总巯基水平较高，但差异不显著。结论：黄芪提取物可提高小鼠学习记忆能力，减轻脑组织病理改变。这可能是由于PM提取物的抗氧化植物化学物质。
The objective of this study was to investigate the effects of Polygonum multiflorum (PM) Thunb. on the learning and memory ability in one- and seven-month-old male senescence accelerated mice (SAMP8). The mice were fed with two different diets for 18 weeks; they were casein dietary group (control group) and casein diet supplemented with PM extracts. Active shuttle avoidance test was performed to determine the learning and memory ability of the mice while the spongy degeneration and the lipofuscin, malondialdehyde, and total thiol levels of the brain were measured to evaluate the extent of the brain degeneration and oxidative status. Results of active shuttle avoidance test showed the mice fed with the PM extracts had significantly better learning and memory ability than the control group. The spongy degeneration and the lipofuscin and malondialdehyde concentrations of the mice in the PM groups were significantly lower than the control in both age groups, whereas the total thiol levels were higher but not significantly different. It was concluded that the supplement of the PM extracts could improve the learning and memory ability and reduce the brain pathological changes in mice. This might be due to the antioxidant phytochemicals of the PM extracts.