Caspase activity plays an essential role in long-term memory
Caspase activity plays an essential role in long-term memory
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DOI：
10.1097/00001756-200008210-00040
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发表时间：
2000-08-21
期刊：
影响因子：
1.7
通讯作者：
Moore, AN
中科院分区：
文献类型：
--
作者：
Dash, PK;Blum, S;Moore, AN
在各种生物体中，细胞内第二信使级联的激活与学习和记忆有关。识别这些在学习和记忆中发挥作用的第二信使的下游靶标是一个活跃的研究领域。最近，有报道称，细胞内钙的增加可以激活半胱氨酸依赖的天冬氨酸导向的蛋白酶(Caspase)级联反应。使用选择性识别激活的caspase-3的抗体，我们检测到这种酶在海马神经元中的存在。抑制海马区的caspase活性阻止了长期的空间记忆，但不是短期的空间记忆。这些结果表明，海马神经元中的半胱氨酸天冬氨酸氨基转移酶介导的细胞事件(S)是长期空间记忆存储的关键。(C)2000年Lippincott Williams&Wilkins。
Activation of intracellular second messenger cascades has been linked to learning and memory in various organisms. Identification of down-stream targets of these second messengers that play a role in learning and memory is an active area of research. Recently, it has been reported that increases in intracellular calcium can activate a cysteine-dependent aspartate-directed protease (caspase) cascade in mice. Using an antibody that selectively recognizes activated caspase-3, we detected the presence of this enzyme in hippocampal neurons. Inhibition of caspase activity in the hippocampus blocked longterm, but not short-term, spatial memory. These results suggest that a caspase-mediated cellular event(s) in hippocampal neurons is critical for long-term spatial memory storage. (C) 2000 Lippincott Williams & Wilkins.