MOUSE IGG3 ANTIBODIES ARE HIGHLY PROTECTIVE AGAINST INFECTION WITH STREPTOCOCCUS-PNEUMONIAE
MOUSE IGG3 ANTIBODIES ARE HIGHLY PROTECTIVE AGAINST INFECTION WITH STREPTOCOCCUS-PNEUMONIAE
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DOI：
10.1038/294088a0
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发表时间：
1981-01-01
期刊：
影响因子：
64.8
通讯作者：
FORMAN, C
中科院分区：
文献类型：
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作者：
BRILES, DE;CLAFLIN, JL;FORMAN, C
碳水化合物和蛋白质抗原已显示在人、小鼠、大鼠和马中以相互排斥的IgG亚类引发其大部分抗体1 -4。在小鼠中，抗蛋白抗体主要是IgG 1亚类，抗碳水化合物抗体主要是IgG 3亚类1，2。我们现在已经证明，小鼠IgG 3抗体的磷酸胆碱（PC）决定簇的肺炎球菌C-碳水化合物5，6和3型肺炎球菌多糖是高度保护对实验性3型肺炎球菌感染。这是第一次证明IgG 3亚类的抗体可以保护免受细菌感染。
Carbohydrate and protein antigens have been shown to elicit the bulk of their antibodies in mutually exclusive IgG subclasses in humans, mice, rats and horses1–4. In the mouse, anti-protein antibodies are primarily of the IgG1 subclass, and anti-carbohydrate antibodies are primarily of the IgG3 subclass1,2. We have now demonstrated that mouse IgG3 antibodies to the phosphocholine (PC) determinant of pneumococcal C-carbohydrate5,6and to type 3 pneumococcal polysaccharide are highly protective against experimental type 3 pneumococcal infection. This is the first demonstration that antibodies of the IgG3 subclass can protect against bacterial infection.