KERATINIZATION
KERATINIZATION
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DOI：
10.1111/1523-1747.ep12512473
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发表时间：
1976-01-01
影响因子：
6.5
通讯作者：
MATOLTSY, AG
中科院分区：
文献类型：
--
作者：
MATOLTSY, AG
早期的研究已经表明马氏细胞的张力原纤维由含有a-SH的纤维性α-蛋白组成。据推测，高抗性保护物质角蛋白是由sh基团转化为- s - s键形成的。这一化学反应被认为是角化过程中最重要的事件。最近的研究表明，角化过程经过一个合成和降解阶段，最终形成一个复杂的保护物质。角质层细胞充满了含sh的细丝，这些细丝嵌入了富含a - s - s的无定形基质中。这种复合物由一层增厚的膜包裹，由于s - s键和一种未知的高抗性键而无法溶解。在角质层中，细胞间隙被双极性脂质占据，这些脂质来自膜覆盖颗粒排出的薄片。
Early studies have already shown that the tonofibrils of malpighian cells consist of a—SH containing fibrous α-protein. It was assumed that the highly resistant protective substance, keratin, was formed by the conversion of—SH groups into —S—S—bonds in this protein. This chemical reaction was regarded as the most significant event of the keratinization process. Recent studies show that keratinization proceeds by a synthetic and a degradative stage and that ultimately a complex protective substance is formed. Horny cells become filled with—SH-containing filaments embedded in a—S—S—rich amorphous matrix. This complex is encased by a thickened membrane rendered insoluble by—S—S—bonds and an unknown, highly resistant bond. In the stratum corneum, the intercellular space is occupied by bipolar lipids originating from the discharged lamellae of membrane-coating granules.