HEART SPHINGOLIPIDS IN HEALTH AND DISEASE
HEART SPHINGOLIPIDS IN HEALTH AND DISEASE
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DOI：
10.1007/978-1-4614-0650-1_3
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发表时间：
2011-01-01
期刊：
影响因子：
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通讯作者：
Gorski, Jan
中科院分区：
文献类型：
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作者：
Baranowski, Marcin;Gorski, Jan
近年来，鞘脂在心脏生理和病理生理中的作用备受关注。神经酰胺参与了缺血再灌注损伤、2型糖尿病和脂毒性心肌病动物模型心功能障碍的发生。另一方面，该脂类家族的另一成员，即鞘氨醇-1-磷酸，已被证明具有有效的心脏保护特性。本章综述了神经酰胺和其他生物活性鞘脂在心脏生理和病理生理中的作用。我们描述了ppar和运动在调节心肌鞘脂代谢中的作用。我们还总结了神经酰胺和鞘氨醇-1-磷酸在心脏缺血/再灌注损伤的发生和预防中的作用。在本章的最后一节，我们讨论神经酰胺在心肌脂肪毒性中的作用的证据。
In recent years, the role of sphingolipids in physiology and pathophysiology of the heart attracted much attention. Ceramide was found to be involved in the pathogenesis of cardiac dysfunction in animal models of ischemia/reperfusion injury, Type 2 diabetes and lipotoxic cardiomyopathy. On the other hand, another member of this lipid family, namely sphingosine-1-phosphate, has been shown to possess potent cardioprotective properties. This chapter provides a review of the role of ceramide and other bioactive sphingolipids in physiology and pathophysiology of the heart. We describe the role of PPARs and exercise in regulation of myocardial sphingolipid metabolism. We also summarize the present state of knowledge on the involvement of ceramide and sphingosine-1-phosphate in the development and prevention of ischemia/reperfusion injury of the heart. In the last section of this chapter we discuss the evidence for a role of ceramide in myocardial lipotoxicity.