Impact of antioxidative supplementation on semen quality according to MSOME criteria Improvement of semen parameters by dietary supplement
Impact of antioxidative supplementation on semen quality according to MSOME criteria Improvement of semen parameters by dietary supplement
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DOI：
10.5935/1518-0557620130003
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发表时间：
2013-01-01
影响因子：
1.5
通讯作者：
Zech, Nicolas Herbert
中科院分区：
文献类型：
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作者：
Ajayi, Richardson;Okhowat, Jasmin;Zech, Nicolas Herbert
目的：探讨口服抗氧化剂和微量营养素对体外受精（IVF）患者精液质量的影响。方法：对160例体外受精患者进行IVF/IMSI（胞浆内形态学选择精子注射）周期前2-12个月的精子分析。按MSOME标准分析精液量、精子浓度、活力和形态。根据WHO标准，患者被分为正常精子、少弱无精子症（OAT）少精症和弱精子症。在第一次和第二次精液分析之间，患者口服膳食抗氧化剂补充剂。采用学生t检验评价数据的显著性。结果：在患者总数中，我们发现抗氧化治疗后，不动精子的百分比显著降低，精子总活力显著增加。我们还观察到少精子症、弱精子症和OAT患者精液的活力、精子浓度和精子形态（根据MSOME标准）有了显著改善。对于无精子患者，我们发现精子参数几乎没有显著增加。结论：膳食补充后的精液质量，如活力、精子浓度和形态有明显改善，特别是在精液质量较差的IVF患者中。体外受精患者精子质量的改善对辅助生殖技术（ART）有至关重要的影响。我们的研究结果表明，补充微量营养素通常对接受抗逆转录病毒治疗的男性精液质量有益，但主要是对精子参数改变程度较高的男性有益。建议的作用方式可能是由于氧化应激的下降。
Purpose: To investigate the influence of an oral antioxidative and micronutrient supplementation on semen quality assessed by MSOME (motile sperm organelle morphology examination) criteria in a collective of in vitro fertilization (IVF) patients.Methods: Sperm analysis of 160 IVF patients was evaluated 2-12 months before undergoing IVF/IMSI (intracytoplasmic morphologically selected sperm injection) cycle. The following parameters were analyzed: semen volume, sperm concentration, motility and morphology according to MSOME criteria. Patients were grouped according to the WHO criteria into normozoospermic, oligoasthenoteratozoospermic (OAT) oligo- and asthenozoospermic men, respectively. Between first and second semen analysis, patients were treated orally with a dietary antioxidative supplement. The Student's t-test was used to evaluate the significance of data.Results: In the total number of patients we found a significant reduction in the percentage of immotile sperms and a highly significant increase of total sperm motility after antioxidative therapy. We also observed substantial improvement of motility, the sperm concentration as well as sperm morphology (according to MSOME criteria) in the semen of oligozoospermic, asthenozoospermic and OAT patients. For normozoospermic patients, we found almost no significant increase in sperm parameters.Conclusions: The results display a considerable improvement in semen quality, such as motility, sperm concentration and morphology after dietary supplementation, notably in IVF patients with poor semen quality. Amelioration of sperm quality of IVF patients can have a crucial impact in assisted reproductive technology (ART). Our findings suggest that micronutrient supplementation might be generally beneficial for semen quality in men undergoing ART, but mostly in those with a higher grade of alterations in their sperm parameters. The suggested mode of action is probably due to a decline of oxidative stress.