Bile-induced curing of the virulence plasmid in Salmonella enterica serovar Typhimurium
Bile-induced curing of the virulence plasmid in Salmonella enterica serovar Typhimurium
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DOI：
10.1128/jb.00995-06
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发表时间：
2006-11-01
影响因子：
3.2
通讯作者：
Casadesus, Josep
中科院分区：
文献类型：
--
作者：
Garcia-Quintanilla, Meritxell;Prieto, Ana I.;Casadesus, Josep
暴露于胆汁诱导肠道沙门氏菌鼠伤寒血清型（pH14）中毒力质粒的治愈。中断的ccdB基因增加peptide治愈，自发的和诱导的胆汁，这表明peptide ccdAB基因可能编码的CedAB成瘾模块的同源物先前描述的F性因子。与F性因子不同，pSLT编码的皮利的合成不赋予胆汁敏感性。这些观察结果可能会提供洞察沙门氏菌亚种1的毒力质粒的演变，以及其他沙门氏菌亚种的毒力质粒丢失的原因。
Exposure to bile induces curing of the virulence plasmid in Salmonella enterica serovar Typhimurium (pSLT). Disruption of the ccdB gene increases pSLT curing, both spontaneous and induced by bile, suggesting that the pSLT ccdAB genes may encode a homolog of the CedAB addiction module previously described in the F sex factor. Unlike the F sex factor, synthesis of pSLT-encoded pili does not confer bile sensitivity. These observations may provide insights into the evolution of virulence plasmids in Salmonella subspecies 1, as well as the causes of virulence plasmid loss in other Salmonella subspecies.