MRI quantification of fatty infiltration and muscle atrophy in a mouse model of rotator cuff tears
MRI quantification of fatty infiltration and muscle atrophy in a mouse model of rotator cuff tears
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DOI：
10.1002/jor.22233
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发表时间：
2013-03-01
影响因子：
2.8
通讯作者：
Feeley, Brian T.
中科院分区：
文献类型：
--
作者：
Samagh, Sanjum P.;Kramer, Erik J.;Feeley, Brian T.
肩袖病变是骨科医生最常见的肩关节问题。肩袖肌脂肪浸润和肌肉萎缩在较大撕裂中很常见，被认为是肩袖修复预后的预测因素。在临床上，MRI是确定脂肪浸润和肌肉萎缩的金标准;然而，MRI成像的分析主要是定性的，结果缺乏进一步的验证。我们最近开发了一种肩袖撕裂的小鼠模型。本研究的目的是在我们的小鼠模型中使用高分辨率MRI量化和验证肩袖肌肉萎缩和脂肪浸润。使用甘油三酯定量测定（TQA）分析肩袖肌肉的脂肪，通过水置换（WD）和组织学测量肌肉体积。该研究显示，MRI与脂肪组织学和TQA测量具有高度相关性（R2 =？098）。MRI也与WD和湿重测量的萎缩相关性良好。这表明，MRI是一种可靠的方式，在评估小动物模型肩袖撕裂后脂肪浸润和肌肉萎缩的进展。(C)2012骨科研究学会。由威利期刊公司出版J Orthop Res 31：421426，2013
Rotator cuff pathology is the most common shoulder problem seen by orthopedic surgeons. Rotator cuff muscle fatty infiltration and muscle atrophy are common in larger tears and are considered predicting factors for the prognosis of cuff repair. Clinically, MRI is the gold standard in determining fatty infiltration and muscle atrophy; however, analysis for MRI imaging is primarily qualitative in nature with the results lacking further validation. We have recently developed a mouse model of rotator cuff tears. The goal of this study is to quantify and verify rotator cuff muscle atrophy and fatty infiltration using high-resolution MRI in our mouse model. The rotator cuff muscles were analyzed for fat using a triglyceride quantification assay (TQA), muscle volume was measured through water displacement (WD), and histology. The study revealed that MRI had a high correlation with fat as measured with histology and TQA (R2?=?098). MRI also correlated well with atrophy measured with WD and wet weight. This suggests that MRI is a reliable modality in evaluating the progression of fatty infiltration and muscle atrophy following rotator cuff tears in a small animal model. (C) 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31: 421426, 2013