Neuroelectric correlates of response production and inhibition in individuals at risk to develop alcoholism
Neuroelectric correlates of response production and inhibition in individuals at risk to develop alcoholism
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DOI：
10.1016/s0006-3223(96)00221-1
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发表时间：
1997-07-01
影响因子：
10.6
通讯作者：
Wang, WY
中科院分区：
文献类型：
--
作者：
Cohen, HL;Porjesz, B;Wang, WY
P300 记录是对酗酒高风险 (HR) 的前排雄性和低风险 (LR) 对照进行的，参与视觉进行/不进行反应时间范式。 go（按下按钮）和no go（抑制反应）刺激是相同字母的大号和小号形式。 LR 组在中央、顶叶和颞区的 P300 振幅明显大于不进行的 P300 振幅； HR组在任何区域都没有表现出反应差异，LR组与HR组相比，整个头部的go和no go反应幅度都更大；在任何区域都没有观察到潜伏期的组间差异，表面能幅度与 P300 幅度平行，并且在进行和不进行试验期间 LR 组的表面能幅度也更大。我们的研究结果表明，HR 个体在执行简单的信息处理范例时表现出广泛的 P300 幅度缺陷。这些缺陷可能反映了遗传影响，出现在酗酒之前，并且可能作为其发展的表型标记。 (C) 1997 年生物精神病学协会。
P300 recordings were made front males at high risk (HR) for alcoholism and low-risk (LR) controls, participating in a visual go/no go reaction time paradigm. The go (button press) and no go (inhibit response) stimuli were large and small forms of the same letters. The LR group had significantly larger go than no go P300 amplitudes in the central, parietal, and temporal regions; the HR group manifested no response differences in any region, In the LR group compared to the HR group, both go and no go response amplitudes were larger over the entire head; no group differences in latencies were observed in any region, Surface energy magnitudes paralleled P300 amplitudes and were also larger in the LR group during both go and no go trials, Our findings indicate that HR individuals manifest widespread P300 amplitude deficits while performing a simple information-processing paradigm. These deficits, which may reflect genetic influences, preceded the onset of alcoholism and may function as a phenotypic marker for its development. (C) 1997 Society of Biological Psychiatry.