The Glycolytic Phenotype is Correlated with Aggressiveness and Poor Prognosis in Invasive Ductal Carcinomas
The Glycolytic Phenotype is Correlated with Aggressiveness and Poor Prognosis in Invasive Ductal Carcinomas
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DOI：
10.4048/jbc.2012.15.2.172
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发表时间：
2012-06-01
影响因子：
2.4
通讯作者：
Paik, Seung Sam
中科院分区：
文献类型：
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作者：
Jang, Se Min;Han, Hulin;Paik, Seung Sam
目的：癌细胞中葡萄糖摄取和糖酵解代谢增强，葡萄糖转运蛋白1 （GLUT1）表达增加也有报道。本研究的目的是探讨GLUT1在人乳腺组织和浸润性导管癌中的表达。方法：采用组织微阵列技术，包括正常乳腺组织、导管增生组织、导管原位癌组织、浸润性导管癌组织和淋巴结转移组织。我们通过免疫组织化学检测了GLUT1在微阵列中的表达，查阅了医疗记录并进行了临床病理分析。结果：GLUT1在正常细胞和肿瘤细胞中均有膜性表达。GLUT1在导管原位癌、浸润性导管癌和淋巴结转移组织中的表达高于正常组织和导管增生组织（p=0.002）。276例浸润性导管癌中，106例（38.4%）表达GLUT1。GLUT1的表达与较高的组织学分级相关(p
Purpose: Glucose uptake and glycolytic metabolism are enhanced in cancer cells, and increased expression of glucose transporter 1 (GLUT1) has also been reported. The aim of this study was to investigate GLUT1 expression in human breast tissues and invasive ductal carcinomas. Methods: We used tissue microarrays consisting of normal breast tissue, ductal hyperplasia, ductal carcinoma in situ, invasive ductal carcinoma, and lymph node metastases. We examined GLUT1 expression in the microarrays by immunohistochemistry, reviewed the medical records and performed a clinicopathological analysis. Results: Membranous GLUT1 expression was observed in normal and tumor cells. GLUT1 expression was higher in ductal carcinoma in situ, invasive ductal carcinoma, and lymph node metastasis than in normal tissue and ductal hyperplasia (p=0.002). Of 276 invasive ductal carcinomas, 106 (38.4%) showed GLUT1 expression. GLUT1 expression was correlated with higher histologic grade (p