Oncogenes and human cancer: cause or consequence?
Oncogenes and human cancer: cause or consequence?
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癌基因和人类癌症：原因还是结果？
DOI：
10.1093/carcin/7.7.1037
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发表时间：
1986
期刊：
影响因子：
4.7
通讯作者：
Barbacid,M
中科院分区：
文献类型：
--
作者：
Barbacid,M
在过去的五年中，我们目睹了一系列科学发展，这些发展首次使揭示人类肿瘤发生所涉及的分子事件成为可能。在这些科学发展中，人类肿瘤中癌基因的鉴定和随后的表征占据了最突出的位置。癌基因的概念起源于近20年前开始的急性转化逆转录病毒的工作（见1，2的评论）。遗传学和生物化学证据无疑确定了病毒基因组中存在一个小区域，其表达足以引发致癌作用。迄今为止，至少有20种逆转录病毒癌基因已被鉴定和表征，特别是自重组DNA技术出现以来（2）。然而，许多研究人员仍然怀疑癌基因研究对我们理解人类癌症的重要性。毕竟，逆转录病毒定义的癌基因的概念与人类恶性肿瘤的多阶段性严重冲突。
During the last five years we have witnessed a series of scientific developments that are making possible for the first time the unveiling of molecular events involved in the onset of human neoplasia. Identification and subsequent characterization of oncogenes in human tumors occupies the most prominent place among these scientific developments.The concept of oncogene emanated from work started almost 20 years ago with acute transforming retroviruses (see 1, 2 for reviews). Genetic and biochemical evidence unquestionably defined the existence of a small region in the viral genome whose expression was sufficient to trigger carcinogenesis. At least 20 retroviral oncogenes have been identified and characterized so far, particularly since the advent of recombinant DNA technology (2). However, many investigators have remained skeptical about the significance of oncogene research in regard to our understanding of human cancer. After all, the concept of oncogene as defined by retroviruses is in serious conflict with the multi-stage nature of human malignancies.