Risk Factors of Health-Related Quality of Life among Gastrointestinal Cancer Survivors in the U.S.: With a Focus on Social and Behavioral Determinants of Health (SBDH).
Risk Factors of Health-Related Quality of Life among Gastrointestinal Cancer Survivors in the U.S.: With a Focus on Social and Behavioral Determinants of Health (SBDH).
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美国胃肠道癌幸存者中与健康相关的生活质量的危险因素：重点是卫生的社会和行为决定因素（SBDH）。
DOI：
10.3390/ijerph20176676
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发表时间：
2023-08-29
影响因子：
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通讯作者：
Von Ah, Diane
中科院分区：
文献类型：
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作者：
Han, Claire J;Tounkara, Fode;Kalady, Matthew;Noonan, Anne M;Burse, Natasha R;Paskett, Electra D;Von Ah, Diane
工作背景：越来越多的长期胃肠道（GI）癌症幸存者强调了了解影响其健康相关生活质量（HRQoL）的因素的重要性。我们调查了HRQoL的危险因素，包括人口统计学、临床特征以及健康的社会和行为决定因素（SBDH）。研究方法：分析了2014-2021年（2015年除外）行为风险因素监测系统（BRFSS）调查中成年GI癌症幸存者（n = 3201）的数据。使用未校正/校正logistic回归。结果：大多数是女性（54%）和白色（78%），中位年龄为67岁。65岁或以上、诊断为结直肠癌或合并症较少的幸存者更有可能报告显著更好的HRQoL。HRQoL差的重要社会因素包括未婚、种族和少数民族、社会经济地位差和医疗服务差。HRQoL差的重要行为因素是缺乏体力活动、大量饮酒和当前吸烟，其中缺乏体力活动是最重要的因素。结论：SBDH在HRQoL中具有关键作用。未来的研究有必要开发量身定制的生存干预措施，如身体康复，并探索基于机器学习/人工智能的预测模型，以确定发展不良HRQoL的高风险癌症幸存者。
Background: Increasing numbers of long-term gastrointestinal (GI) cancer survivors highlight the importance of understanding the factors contributing to their health-related quality of life (HRQoL). We investigated the risk factors of HRQoL, including demographics, clinical characteristics, and social and behavioral determinants of health (SBDH). Methods: Data on adult GI cancer survivors (n = 3201) from the Behavioral Risk Factors Surveillance System (BRFSS) surveys from 2014–2021 (except for 2015) were analyzed. Unadjusted/adjusted logistic regression was used. Results: The majority were women (54%) and white (78%), with a median age of 67. Survivors who were 65 years or older, diagnosed with colorectal cancer, or who had fewer comorbidities were more likely to report significantly better HRQoL. Significant social factors of poor HRQoL included unmarried, racial and ethnic minorities, poor socioeconomic status, and poor healthcare access. Significant behavioral factors of poor HRQoL were lack of physical activity, heavy alcohol consumption, and current smoking, with lack of physical activity being the most significant factor. Conclusions: The SBDH has a critical role in HRQoL. Future studies are warranted to develop a tailored survivorship intervention, such as physical rehabilitation, and to explore machine learning/artificial intelligence-based predictive models to identify cancer survivors at a high risk of developing poor HRQoL.