Effects of gender on the severity of sepsis
Effects of gender on the severity of sepsis
复制标题
DOI：
10.1007/s00595-004-2958-3
复制
发表时间：
2005-06-01
期刊：
影响因子：
2.5
通讯作者：
Avunduk, MC
中科院分区：
文献类型：
--
作者：
Erikoglu, M;Sahin, M;Avunduk, MC
目的。目的观察性激素对脓毒症大鼠肺、肝组织变化的影响，探讨雌雄之间的差异。将60只SD大鼠随机分为6组，每组10只。第1、2组为对照组，仅造成脓毒症；第3、4组分别为脓毒症男性和女性组，然后肌肉注射雌激素+孕酮(E-P)0.04 mg/kg；第5、6组分别为男性和女性组，脓毒症后再注射0.5 mg/kg睾酮(T)。处死大鼠，观察肺、肝组织病理变化，检测血浆内毒素水平。组织病理学检查显示，E-P组的充血、门脉炎症和肝脏局灶性坏死明显少于其他两组，肺充血、水肿、肺气肿和炎性改变明显少于其他两组。此外，雌性大鼠和E-P组大鼠血浆全身性内毒素血症的体征明显少于雄性大鼠和T组。由于雌性性激素的影响，雌性脓毒症大鼠比雄性大鼠肝和肺组织损伤更少，全身内毒素血症更少。
Purpose. To investigate the differences between male and female rats and the effects of sex hormones on tissue changes in the lung and liver in a sepsis model.Methods. Sixty Sprague-Dawley rats were divided into six groups of ten. Groups 1 and 2 were the control male and female groups, respectively, subjected only to sepsis; groups 3 and 4 were the male and female groups, respectively, subjected to sepsis, then given 0.04 mg/kg estrogen + progesterone (E-P) intramuscularly (i.m.); and groups 5 and 6 were the male and female groups, respectively, subjected to sepsis, then given 0.5 mg/kg testosterone ( T) i.m. The rats were killed and the histopathological changes in the lung and liver were examined, and plasma endotoxin levels were measured.Results. Histopathological examination revealed less congestion, portal inflammation, and focal necrosis of the liver, and less congestion, edema, and emphysematous and inflammatory changes in the lung in the E-P groups than in the other groups. Moreover, signs of systemic endotoxemia in plasma were proportionally less in the female rats and in the E-P groups than in the male rats and the T groups.Conclusion. Female rats subjected to sepsis showed less liver and lung tissue damage and less systemic endotoxemia than male rats, because of the effects of female sex hormones.