Bone and soft tissue changes with oral phosphate supplements.
Bone and soft tissue changes with oral phosphate supplements.
复制标题
口服磷酸盐补充剂会改变骨骼和软组织。
DOI：
10.1172/jci107106
复制
发表时间：
1972
期刊：
影响因子：
--
通讯作者：
J. Jowsey
中科院分区：
文献类型：
--
作者：
G. Laflamme;J. Jowsey
成年犬分次口服磷酸盐补充剂10个月。骨密度，骨转换，血清化学值，和软组织的钙含量进行了测定，并在实验期结束时。血清钙保持不变，血清磷略有下降，但显着。与实验前值相比，磷酸盐减少与骨吸收增加有关，这在所有犬的尺骨末端和髂嵴骨样本中均观察到。补充磷酸盐5个月和10个月后，血清免疫反应性甲状旁腺激素增加（与实验前值相比）;这种增加与骨丢失和血清磷酸盐减少有关。组织学上可在肾脏和眼睛的透镜中发现软组织钙化，从而导致白内障。胸主动脉、肾脏、心脏和肌腱中的钙含量增加，但骨骼肌中的钙含量未增加。成年狗补充磷酸盐似乎会引起继发性甲状旁腺功能亢进、骨丢失和软组织钙化。
Oral phosphate supplements in divided doses were given to adult dogs for a period of 10 months. Bone density, bone turnover, serum chemistry values, and the calcium content of soft tissues were determined initially and at the end of the experimental period. Serum calcium remained the same; serum phosphate decreased slightly but significantly. The decrease in phosphate was related to an increase, compared with pre-experimental values, in bone resorption which was seen in the terminal ulna and iliac crest bone samples from all dogs. Serum immunoreactive parathyroid hormone was increased (compared with pre-experimental values) after 5 and 10 months of phosphate supplementation; this increase was related to the bone loss and the decrease in serum phosphate. Soft-tissue calcification could be demonstrated histologically in the kidney and in the lens of the eye where it resulted in cataracts. Calcium content increased in the thoracic aorta, kidney, heart, and tendon but not in skeletal muscle. Phosphate supplements in adult dogs appear to produce secondary hyperparathyroidism, bone loss, and calcification of soft tissues.