Wisconsin card sorting test in children with temporal lobe epilepsy
Wisconsin card sorting test in children with temporal lobe epilepsy
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DOI：
10.1016/s0387-7604(02)00024-4
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发表时间：
2002-04-01
影响因子：
1.7
通讯作者：
Kashima, H
中科院分区：
文献类型：
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作者：
Igarashi, K;Oguni, H;Kashima, H
为探讨威斯康星卡片分类试验(WCST)确定的颞叶癫痫(TLE)患儿额叶功能障碍的来源，我们对19例TLE患儿(有海马萎缩(HA组)12例，无结构损害(NSL组)7例)和15例额叶癫痫(FLE组)进行了WCST检查。和年龄匹配的正常对照组(N组)。同时进行配对言语联想学习测验(PVALT)和本顿视觉保持测验(BVRT)。HA组和FLE组在WCST上获得的类别数显著少于NSL组和N组，而在WCST上表现出更多的持久性错误，并且HA组的WCST类别成绩与惊厥开始时的年龄呈显著负相关(P<；0，05)。在PVALT和BVRT方面，HA组和FLE组之间差异无统计学意义(P>；0.05)。因此，在HA组中，额叶功能障碍早在7岁时就被发现，当时他们似乎只有很短的癫痫史或受到从颞叶焦点到额区的少量电干扰。这些事实将强调前额叶功能障碍的重要性，从早期的侮辱开始，直到内侧TLE患者的前额叶区域成熟后才变得明显。(C)2002 Elsevier Science B.V.保留所有权利。
To search for the origin of frontal lobe dysfunction identified by the Wisconsin card sorting test (WCST) in temporal lobe epilepsy (TLE) patients, we investigated the WCST performance among 19 children with TLE (with hippocampal atrophy (HA group N = 12), without structural lesions (NSL group N = 7)), 15 patients with frontal lobe epilepsy (FLE group). and age-matched normal controls (N group). The paired verbal association learning test (PVALT) and Benton visual retention test (BVRT) were also performed. HA group and FLE groups achieved significantly fewer categories and demonstrated more perseverative errors on the WCST than NSL and N groups, In addition, category achievement in WCST showed significant inverse correlation to age at the initial status convulsivus in the HA group (P < 0,05). The achievement on PVALT and BVRT did not show any significant differences between HA and FLE groups (P > 0.05). Thus, the frontal lobe dysfunction in the HA group is found to exist as early as 7 years old, when they seem to have only a short seizure history or to receive a little electrical interference from the temporal lobe focus to the frontal region. These fact, would underscore the importance of prefrontal dysfunction persisting from the early insults and only becoming apparent after maturation of the prefrontal region in patients with mesial TLE. (C) 2002 Elsevier Science B.V. All rights reserved.