Glutamate and aspartate are decreased in the skin in amyotrophic lateral sclerosis.
Glutamate and aspartate are decreased in the skin in amyotrophic lateral sclerosis.
复制标题
肌萎缩侧索硬化症患者皮肤中的谷氨酸和天冬氨酸减少。
DOI：
10.1111/j.1600-0404.1992.tb05128.x
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发表时间：
1992
影响因子：
3.5
通讯作者：
Yamauchi,M
中科院分区：
文献类型：
--
作者：
Ono,S;Yamauchi,M
我们测量了8名肌萎缩性侧索硬化症（ALS）患者和7名对照组活检皮肤中的氨基酸水平。ALS患者最显著的变化如下：首先，在ALS患者中，酸性氨基酸谷氨酸和天冬氨酸的含量显著降低，且与病程呈显著负相关。其次，与胶原蛋白相关的氨基酸羟脯氨酸、脯氨酸、甘氨酸、丙氨酸和羟赖氨酸的水平在ALS患者中显著降低，且与病程呈负相关。这些结果表明，ALS患者的皮肤中存在酸性氨基酸和胶原蛋白相关氨基酸的异常。这些变化可能是ALS发病机制的基础。
We measured the levels of amino acids in biopsied skin from eight patients with amyotrophic lateral sclerosis (ALS) and seven controls. The most conspicuous changes in ALS patients were as follows. First, the contents of the acidic amino acids glutamate and aspartate were significantly decreased in ALS, and were negatively and significantly associated with the duration of illness. Second, the levels of the collagen‐associated amino acids hydroxyproline, proline, glycine, alanine, and hydroxylysine were significantly decreased in ALS, and correlated inversely with the duration of illness. These results suggest that there are abnormalities of acidic amino acids and collagen‐associated amino acids in the skin of patients with ALS. These changes may underlie the pathogenesis of ALS.