Sex-specific developmental changes in amygdala responses to affective faces
Sex-specific developmental changes in amygdala responses to affective faces
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DOI：
10.1097/00001756-200102120-00047
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发表时间：
2001-02-12
期刊：
影响因子：
1.7
通讯作者：
Yurgelun-Todd, DA
中科院分区：
文献类型：
--
作者：
Killgore, WDS;Oki, M;Yurgelun-Todd, DA
据推测，青少年的发展涉及大脑功能的重新分配，从较低的皮层下结构到前额叶皮层的较高区域，以提供对情绪行为的更大的自我控制。我们进一步假设，这种再分配可能是由性别特异性激素的变化。为了研究情感处理中的性别差异，19名儿童和青少年在观看表达恐惧的面部照片时接受了功能磁共振成像。在青少年成熟期，男性和女性的杏仁核与前额叶激活模式不同。随着年龄的增长，女性表现出一个渐进的增加，前额叶相对于杏仁核激活在左半球，而男性未能显示出显着的年龄相关的差异。在青春期，情感相关的前额叶-杏仁核回路的功能成熟似乎存在性别差异。NeuroReport 12：427-433（C）2001 Lippincott威廉姆斯和威尔金斯。
It is hypothesized that adolescent development involves a redistribution of cerebral functions from lower subcortical structures to higher regions of the prefrontal cortex to provide greater self-control over emotional behavior. We further hypothesized that this redistribution is likely to be moderated by sex-specific hormonal changes. To examine developmental sex differences in affective processing, 19 children and adolescents underwent fMRI while viewing photographs of faces expressing fear. Males and females differed in the pattern of their amygdala vs prefrontal activation during adolescent maturation. With age, females showed a progressive increase in prefrontal relative to amygdala activation in the left hemisphere, whereas males failed to show a significant age related difference. There appear to be sex differences in the functional maturation of affect-related prefrontal-amygdala circuits during adolescence. NeuroReport 12:427-433 (C) 2001 Lippincott Williams & Wilkins.