The pup-proteasome system of Mycobacterium tuberculosis.
The pup-proteasome system of Mycobacterium tuberculosis.
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DOI：
10.1007/978-94-007-5940-4_10
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发表时间：
2013
影响因子：
--
通讯作者：
Darwin, K Heran
中科院分区：
文献类型：
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作者：
Samanovic, Marie I;Li, Huilin;Darwin, K Heran
蛋白酶体是存在于所有古细菌和真核生物中的依赖atp的蛋白质降解机器，在放线菌目的几种细菌中也发现了蛋白酶体。结核分枝杆菌（Mtb）是一种对人类致病的放线菌，它需要蛋白酶体的功能来致病。在本章中，我们描述了目前对结核分枝杆菌蛋白酶体的生物化学及其在毒力中的作用的了解。Mtb蛋白酶体的特性导致发现蛋白质可以被细菌中的小蛋白质修饰剂降解，就像它们在真核生物中一样。此外，对Mtb中蛋白酶体功能的理解有助于揭示宿主如何对抗感染的新见解。
Proteasomes are ATP-dependent protein degradation machines present in all archaea and eukaryotes, and found in several bacterial species of the order Actinomycetales. Mycobacterium tuberculosis (Mtb), an Actinomycete pathogenic to humans, requires proteasome function to cause disease. In this chapter, we describe what is currently understood about the biochemistry of the Mtb proteasome and its role in virulence. The characterization of the Mtb proteasome has led to the discovery that proteins can be targeted for degradation by a small protein modifier in bacteria as they are in eukaryotes. Furthermore, the understanding of proteasome function in Mtb has helped reveal new insight into how the host battles infections.