Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells
Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells
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DOI：
10.1038/nm880
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发表时间：
2003-06-01
期刊：
影响因子：
82.9
通讯作者：
Siliciano, RF
中科院分区：
文献类型：
--
作者：
Siliciano, JD;Kajdas, J;Siliciano, RF
潜伏的HIV-1持续存在于静止的记忆CD4(+)T细胞中，即使在接受高效抗逆转录病毒治疗(HAART)的患者中也是如此。目前尚不清楚这个潜伏的水库有多稳定，也不清楚它的持续是否反映了低水平病毒血症的补充。在这里，我们表明，即使在接受治疗的患者中，长达7年的时间没有检测到病毒血症，储存库腐烂得如此缓慢(t(1/2)=44个月)，以至于不太可能根除。
Latent HIV-1 persists in resting memory CD4(+) T cells, even in patients receiving highly active antiretroviral therapy (HAART). It has been unclear how stable this latent reservoir is and whether its persistence reflects replenishment by low-level viremia. Here we show that even in treated patients who have had no detectable viremia for as long as 7 years, the reservoir decays so slowly (t(1/2) = 44 months) that eradication is unlikely.