Factors contributing to the immunogenicity of meningococcal conjugate vaccines.
Factors contributing to the immunogenicity of meningococcal conjugate vaccines.
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DOI：
10.1080/21645515.2016.1153206
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发表时间：
2016-07-02
影响因子：
4.8
通讯作者：
Costantino P
中科院分区：
文献类型：
--
作者：
Bröker M;Berti F;Costantino P
已经开发了各种糖蛋白缀合物疫苗用于预防侵袭性脑膜炎球菌病，其相对于纯多糖疫苗具有显著优势。缀合物疫苗的最重要的特征之一是诱导T细胞依赖性免疫应答，这使得能够诱导免疫记忆和重复免疫后的加强应答。与多糖化学连接的载体蛋白的性质通常被认为是决定疫苗免疫原性的主要成分。然而，其他因素可能对疫苗的特征产生重大影响。在这篇综述中，我们探讨了脑膜炎球菌结合疫苗的物理化学性质，这可以显着地有助于疫苗的免疫原性。我们证明了载体不是疫苗特性的唯一决定因素，而且结合疫苗的免疫原性是多种理化结构和特征的结果。
Various glycoprotein conjugate vaccines have been developed for the prevention of invasive meningococcal disease, having significant advantages over pure polysaccharide vaccines. One of the most important features of the conjugate vaccines is the induction of a T-cell dependent immune response, which enables both the induction of immune memory and a booster response after repeated immunization. The nature of the carrier protein to which the polysaccharides are chemically linked, is often regarded as the main component of the vaccine in determining its immunogenicity. However, other factors can have a significant impact on the vaccine's profile. In this review, we explore the physico-chemical properties of meningococcal conjugate vaccines, which can significantly contribute to the vaccine's immunogenicity. We demonstrate that the carrier is not the sole determining factor of the vaccine's profile, but, moreover, that the conjugate vaccine's immunogenicity is the result of multiple physico-chemical structures and characteristics.