The histological findings in normal skin and multiple superficial basal cell carcinoma treated with an ointment containing demecolcine.
The histological findings in normal skin and multiple superficial basal cell carcinoma treated with an ointment containing demecolcine.
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用含有 demecolcine 的软膏治疗正常皮肤和多发性浅表基底细胞癌的组织学结果。
DOI：
10.1159/000255403
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发表时间：
1959
期刊：
影响因子：
--
通讯作者：
R. Jackson
中科院分区：
文献类型：
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作者：
R. Jackson
背景地美秋水仙碱（Demecolcine）[1]（desacetylmethylcolchicine）是从秋水仙（Colchicum autum nale）中提取的一种生物碱。秋水仙碱是从同一种植物中获得的另一种生物碱。这两种生物碱通过在分裂期阻断细胞分裂对有丝分裂具有抑制作用[la]，特别是在癌中[2]。Demecolcine对正常组织的毒性要小得多，但具有大致相同的抑制作用[3]。在临床上，几篇文献[4-7]报道了含有地美秋水仙碱的软膏剂在约50%的病例中可以治愈某些浅表皮肤癌，包括多发性浅表基底细胞癌。King和Sullivan [8]简要报道了秋水仙碱在正常皮肤中的组织学发现。他们观察到鬼臼脂素和秋水仙素都有非典型的核固缩有丝分裂像，除了秋水仙素的有丝分裂数比鬼臼脂素的多得多之外，没有区分两者之间的任何基本差异。术语“秋水仙素细胞”用于描述这些细胞。Berres [9]注意到，在Bowen病区域应用0.1%地美柯辛软膏4周后，治疗后活检显示没有Bowen病的证据。表皮在中期显示棘层、坏死区域和任何有丝分裂。在真皮层有炎症反应。尽管在治疗后的活检中没有发现癌，但患者接受了放射治疗，
BackgroundDemecolcine [1](desacetylmethylcolchicine) is an alkaloid derived from Colchicum autum nale (meadow saffron). Colchicine is another alkaloid obtained from the same plant. Both alkaloids have an in hibiting action on mitoses by blocking cell division during m eta phase [la], particularly in carcinomas [2]. Demecolcine is much less toxic to normal tissues, but has about the same inhibiting action [3]. Clinically, several papers [4-7] have reported th at an ointm ent containing demecolcine could, in about 50% of cases, effect a cure in certain superficial skin carcinomas including multiple superficial basal cell carcinoma.King and Sullivan [8] reported briefly oil the histological findings of colchicine in the normal skin. They observed m any atypical pyknotic m itotic figures with both podophyllin and colchicine; and did not distinguish any basis difference between the two, except that the num ber of mitoses was much greater with colchicine than with podophyllin. The term “colchicine cell” was used to describe these cells. After applying 0.1% demecolcine ointm ent to an area of Bowen’s disease for four weeks, Berres [9] noted that the post treatm ent biopsy showed no evidence of Bowen’s disease. The epi dermis did show acanthosis, areas of necrosis, and m any mitoses at the metaphase. There was an inflam m atory reaction in the dermis. Despite the statem ent th at no carcinoma was present in either of the post-treatm ent biopsies, the patient received irradiation therapy with