S6K2: The Neglected S6 Kinase Family Member.
S6K2: The Neglected S6 Kinase Family Member.
复制标题
S6K2：被忽视的 S6 激酶家族成员。
DOI：
10.3389/fonc.2013.00191
复制
发表时间：
2013
影响因子：
4.7
通讯作者：
Seckl MJ
中科院分区：
文献类型：
--
作者：
Pardo OE;Seckl MJ
S6 激酶 2 (S6K2) 是 AGC 激酶超家族的成员。其最接近的同源物 S6K1 多年来已被广泛研究。然而，由于业界相信这两种异构体之间的高度同一性将转化为基本相同的生物学功能，S6K2 在很大程度上被忽视了。然而，最近的研究清楚地强调了这两种蛋白质在体外和体内的作用存在显着差异。这些发现对于我们了解 S6 激酶信号传导以及开发包括癌症在内的多种疾病的治疗策略具有重要意义。在这里，我们将重点关注 S6K2，并回顾蛋白质-蛋白质相互作用以及决定该激酶选择性功能的特定底物。
S6 kinase 2 (S6K2) is a member of the AGC kinases super-family. Its closest homolog, S6K1, has been extensively studied along the years. However, due to the belief in the community that the high degree of identity between these two isoforms would translate in essentially identical biological functions, S6K2 has been largely neglected. Nevertheless, recent research has clearly highlighted that these two proteins significantly differ in their roles in vitro as well as in vivo. These findings are significant to our understanding of S6 kinase signaling and the development of therapeutic strategies for several diseases including cancer. Here, we will focus on S6K2 and review the protein–protein interactions and specific substrates that determine the selective functions of this kinase.