Surfactant abnormalities in idiopathic pulmonary fibrosis, hypersensitivity pneumonitis and sarcoidosis
Surfactant abnormalities in idiopathic pulmonary fibrosis, hypersensitivity pneumonitis and sarcoidosis
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DOI：
10.1034/j.1399-3003.1999.14c14.x
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发表时间：
1999-09-01
影响因子：
24.3
通讯作者：
Seeger, W
中科院分区：
文献类型：
--
作者：
Günther, A;Schmidt, R;Seeger, W
对36例特发性肺纤维化(IPF)、32例过敏性肺炎(HHP)和44例结节病患者的支气管肺泡灌洗液(BALF)的表面活性物质进行了研究，并与29例健康对照组进行了比较。用超速离心法测定大分子表面活性物质聚集体(LSA)，用脉动气泡表面测定仪测定表面活性。与对照组相比，各组的SP-A浓度、LSA含量和PL/蛋白质比均显著降低，而PL和SP-B浓度无明显变化。磷脂组分改变，其中磷脂酰胆碱(不显著)和磷脂酰甘油的百分比降低，磷脂酰肌醇和鞘磷脂的比例增加(p
Bronchoalveolar lavage fluids (BALF) from patients,vith idiopathic pulmonary fibrosis (IPF; n=36), hypersensitivity pneumonitis CHP; n=32) and sarcoidosis (n=44) were investigated for their surfactant properties and compared to healthy control subjects (n=29).The phospholipid (PL) and protein concentration, the PL:protein ratio, PL subclasses, and the surfactant apoproteins (SP)A and SP-B were quantified in BALF. Large surfactant aggregates (LSA) were measured by means of ultracentrifugation and assayed for surface activity using the pulsating bubble surfactometer.As compared to controls, SP-A concentrations, LSA content and PL:protein ratios were significantly decreased in all groups, whereas PL and SP-B concentrations remained unchanged. Changes in the phospholipid profile, with reduced percentages of phosphatidylcholine (not significant) and phosphatidylglycerol and increased fractions of phosphatidylinositol and sphingomyelin (p