Ventral and Dorsal Striatum Networks in Obesity: Link to Food Craving and Weight Gain
Ventral and Dorsal Striatum Networks in Obesity: Link to Food Craving and Weight Gain
复制标题
DOI：
10.1016/j.biopsych.2015.11.020
复制
发表时间：
2017-05-01
影响因子：
10.6
通讯作者：
Verdejo-Garcia, Antonio
中科院分区：
文献类型：
--
作者：
Contreras-Rodriguez, Oren;Martin-Perez, Cristina;Verdejo-Garcia, Antonio
背景技术背景：食物成瘾模型提出，在纹状体的神经生物学改变和相关的临床表现方面，肥胖与成瘾重叠。例如，（1）坚持不健康的生活习惯。因此，我们的目的是研究功能连接的纹状体超重与正常体重的主题，并确定纹状体连接和个体差异的食物渴望和身体质量指数（BMI）的变化之间的关联程度。25)39名正常体重的参与者参加了这项研究。在腹侧和背侧纹状体的功能连接表明种子为基础的分析restingstate数据。食物渴望与高热量食物的视觉线索的主观评级。在28名超重参与者中评估了基线和12周随访期间BMI的变化。在腹侧纹状体和背侧纹状体的连接措施进行了比较组之间的渴望和BMI的变化。结果：超重的参与者表现出腹侧纹状体和内侧前额叶和顶叶皮质之间的功能连接增加，背侧纹状体和体感皮质之间。背侧纹状体连接与食物渴望和预测BMI gains.CONCLUSIONS：肥胖与背侧纹状体网络功能连接的改变有关，背侧纹状体网络功能连接与食物渴望和体重增加有关。这些神经改变与习惯学习有关，因此与肥胖的食物成瘾模型相一致。
BACKGROUND: The food addiction model proposes that obesity overlaps with addiction in terms of neurobiological alterations in the striatum and related clinical manifestations (i. e., craving and persistence of unhealthy habits). Therefore, we aimed to examine the functional connectivity of the striatum in excess-weight versus normal-weight subjects and to determine the extent of the association between striatum connectivity and individual differences in food craving and changes in body mass index (BMI).METHODS: Forty-two excess-weight participants (BMI. 25) and 39 normal-weight participants enrolled in the study. Functional connectivity in the ventral and dorsal striatum was indicated by seed-based analyses on restingstate data. Food craving was indicated with subjective ratings of visual cues of high-calorie food. Changes in BMI between baseline and 12 weeks follow-up were assessed in 28 excess-weight participants. Measures of connectivity in the ventral striatum and dorsal striatum were compared between groups and correlated with craving and BMI change.RESULTS: Participants with excess weight displayed increased functional connectivity between the ventral striatum and the medial prefrontal and parietal cortices and between the dorsal striatum and the somatosensory cortex. Dorsal striatum connectivity correlated with food craving and predicted BMI gains.CONCLUSIONS: Obesity is linked to alterations in the functional connectivity of dorsal striatal networks relevant to food craving and weight gain. These neural alterations are associated with habit learning and thus compatible with the food addiction model of obesity.