Evidence that cyclosporine inhibits cell-mediated immunity primarily at the level of the T lymphocyte rather than the accessory cell.
Evidence that cyclosporine inhibits cell-mediated immunity primarily at the level of the T lymphocyte rather than the accessory cell.
复制标题
有证据表明环孢菌素主要在 T 淋巴细胞而非辅助细胞水平抑制细胞介导的免疫。
DOI：
10.1097/00007890-198808001-00011
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发表时间：
1988
期刊：
影响因子：
6.2
通讯作者：
Steinman,RM
中科院分区：
文献类型：
--
作者：
Granelli-Piperno,A;Keane,M;Steinman,RM
CsA 对细胞介导的免疫的抑制作用是众所周知的。关于CsA是否直接抑制辅助细胞和T淋巴细胞的功能存在争议。我们使用Northern blotting比较了CsA对几种人单核细胞和T细胞mRNA的影响，并进行了“CsA脉冲”实验来分别评估药物在淋巴细胞有丝分裂过程中对辅助细胞和T细胞的影响。
The inhibitory effects of CsA in cell-mediated immunity are well known. There is controversy about whether CsA directly inhibits the function of accessory cells as well as T lymphocytes. We have used northern blotting to compare the effects of CsA on several human monocyte and T cell mRNAs, and we have performed “CsA-pulsing” experiments to separately evaluate the effect of the drug on accessory and T cells during lymphocyte mitogenesis.