Serum osteocalcin level is positively associated with insulin sensitivity and secretion in patients with type 2 diabetes
Serum osteocalcin level is positively associated with insulin sensitivity and secretion in patients with type 2 diabetes
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DOI：
10.1016/j.bone.2010.12.020
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发表时间：
2011-04-01
期刊：
影响因子：
4.1
通讯作者：
Sugimoto, Toshitsugu
中科院分区：
文献类型：
--
作者：
Kanazawa, Ippei;Yamaguchi, Toru;Sugimoto, Toshitsugu
目的：骨作为一种内分泌器官正逐渐被人们所认识。虽然先前的动物研究表明，骨钙素刺激胰岛胰岛素和脂肪细胞脂联素的表达，增加胰岛素分泌和敏感性，但在人类中，血清骨钙素与这些参数的关系尚不清楚。方法：在这项横断面研究中，我们招募了101名绝经后女性和152名未服用糖尿病或骨质疏松药物的2型糖尿病患者。我们还检查了18名绝经后女性和20名男性的75 g口服葡萄糖耐量试验（OGTT），这些患者来我们诊所进行糖尿病医学检查。结果：在绝经后女性和男性中，经年龄、体重指数和血清肌酐校正的多元回归分析显示，血清骨钙素水平与空腹血糖、HbA（1c）、%Trunk脂肪和胰岛素抵抗的稳态模型评估（HOMA）呈显著负相关（p < 0.05），与β细胞功能的HOMA呈正相关（p < 0.05）。此外，绝经后妇女血清骨钙素水平与血清脂联素水平呈显著正相关（p < 0.05），而男性无显著正相关。在OGTT检查中，受试者按男女血清骨钙素水平分为各组。与口服葡萄糖负荷最高的绝经后妇女相比，最低分位的绝经后妇女出现高血糖和高胰岛素血症（p < 0.05）。低不育组的男性也出现高胰岛素血症（p < 0.05），而没有出现高血糖。结论：日本2型糖尿病患者血清骨钙素水平与胰岛素敏感性和胰岛素分泌呈正相关。(C) 2010爱思唯尔公司版权所有。
Objective: Bone is being recognized as an endocrine organ. Although previous animal studies showed that osteocalcin stimulated the expression of insulin in islets and of adiponectin in adipocytes with increased insulin secretion and sensitivity, the associations of serum osteocalcin with those parameters remain unclear in humans.Methods: In this cross-sectional study, we employed 101 postmenopausal women and 152 men with type 2 diabetes, who have not taken drugs for diabetes or osteoporosis. We also examined 75 g oral glucose tolerance test (OGTT) in 18 postmenopausal women and 20 men who visited our clinic for medical check-up for diabetes.Results: In both postmenopausal women and men, multiple regression analysis adjusted for age, body mass index, and serum creatinine showed that serum osteocalcin level was significantly and negatively associated with fasting plasma glucose, HbA(1c), %Trunk fat, and homeostasis model assessment (HOMA) for insulin resistance (p < 0.05), and positively with HOMA for beta-cell function (p < 0.05). In addition, significant positive association of serum osteocalcin level with serum adiponectin level was found in postmenopausal women (p < 0.05), but not in men. In the OGTT examinations, subjects were divided into tertiles by their serum osteocalcin levels in each gender. Postmenopausal women in the lowest tertile showed hyperglycemia and hyperinsulinemia compared to those in the highest tertile after oral glucose loading (p < 0.05). Men in the lowest tertile also exhibited hyperinsulinemia (p < 0.05), while hyperglycemia was not found.Conclusion: These findings indicate that serum osteocalcin level is positively associated with insulin sensitivity and secretion in Japanese patients with type 2 diabetes. (C) 2010 Elsevier Inc. All rights reserved.