The effects of deep barbiturate coma on multimodality evoked potentials.
The effects of deep barbiturate coma on multimodality evoked potentials.
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深度巴比妥昏迷对多模态诱发电位的影响。
DOI：
10.3171/jns.1982.57.2.0178
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发表时间：
1982
影响因子：
4.1
通讯作者：
D. Bruce
中科院分区：
文献类型：
--
作者：
L. Sutton;T. Frewen;R. Marsh;J. Jaggi;D. Bruce
作者报道了大剂量巴比妥酸盐对9只猫多模式诱发反应的影响。在获得基线诱发反应后，定期静脉注射戊巴比妥钠，累积总剂量分别为9、18、27、45、63、123和183 mg/kg。这导致血清戊巴比妥水平逐渐上升，在第五次输液后达到治疗性昏迷水平(4至5 mg/dl)。在这一点上，脑电是平坦的，需要升压药物来维持心血管稳定。在每次注射后15分钟获得诱发反应。脑干听觉诱发反应(Baer)显示在戊巴比妥治疗昏迷时潜伏期几乎没有变化。进一步的巴比妥酸盐导致了这种反应的后期成分的延迟。在躯体感觉诱发反应(SER)中，早期脑干成分相对不受治疗性昏迷程度的影响。晚期脑干成分和初始皮质反应表现为进行性潜伏期延长。晚期皮质(联合皮质)波在相对较低的剂量下被消除。中枢传导时间相对不受影响。小剂量巴比妥酸盐(9 mg/kg)可消除视觉诱发反应(VER)的延迟波。尽管进行了大量的输液，但一个单一的积极-消极复合体仍然存在。结论：诱发反应在监测深度巴比妥酸盐昏迷患者中可能被证明是有用的，但必须记住巴比妥类药物的影响。
The authors report their investigation of the effects of high-dose barbiturates on the multimodality evoked response in 9 cats. After baseline evoked responses were obtained, boluses of pentobarbital were infused intravenously at regular intervals, amounting to cumulative total doses of 9, 18, 27, 45, 63, 123, and 183 mg/kg at respective infusions. This resulted in gradually increasing serum pentobarbital levels, reaching therapeutic coma levels (4 to 5 mg/dl) after the fifth infusion. At this point, the electroencephalogram was flat, and pressor agents were required to maintain cardiovascular stability. Evoked responses were obtained 15 minutes after each infusion. Brain-stem auditory evoked response (BAER) showed little change in wave latencies at therapeutic coma levels of pentobarbital. Further barbiturates resulted in delay of the late components of this response. In the somatosensory evoked responses (SER), early brain-stem components were relatively unaffected by therapeutic coma levels. Late brain-stem components and the initial cortical response showed progressive latency increase. Late cortical (association cortex) waves were abolished at relatively low doses. The central conduction time was relatively unaffected. The late waves of the visual evoked responses (VER) were abolished with low-dose barbiturates (9 mg/kg). A single positive-negative complex persisted despite massive infusions. It is concluded that evoked responses may prove useful in monitoring patients in deep barbiturate coma, but barbiturate effects must be kept in mind.
多模态诱发电位对猫脑干病变的无创定位：与人类头部损伤数据的相关性。
影响因子：
4.1
作者：
Greenberg,RP;Stablein,DM;Becker,DP
通讯作者：
Becker,DP
寒冷引起的脑水肿和白质缺血对体感诱发反应的影响。
影响因子：
4.1
作者：
Sutton,LN;Bruce,DA;Welsh,F
通讯作者：
Welsh,F