Iridium(III)-catalyzed C-7 selective C-H alkynylation of indolines at room temperature.
Iridium(III)-catalyzed C-7 selective C-H alkynylation of indolines at room temperature.
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DOI：
10.1021/jo502596k
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发表时间：
2015-01
期刊：
影响因子：
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通讯作者：
Yunxiang Wu;Ya-xi Yang;Bing Zhou;Yuanchao Li
中科院分区：
文献类型：
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作者：
Yunxiang Wu;Ya-xi Yang;Bing Zhou;Yuanchao Li
首次在室温下通过 C-H 键活化开发了铱催化二氢吲哚的直接 C-7 选择性 C-H 炔基化反应。此外，还实现了咔唑在C1位直接C-H炔基化的第一个例子。更重要的是，所得产物可以很容易地转化为C7-炔基化吲哚，进一步拓宽吲哚的C-7衍生化并突出该方法的合成效用。
An iridium-catalyzed direct C-7 selective C-H alkynylation of indolines at room temperature, for the first time, has been developed via C-H bond activation. Furthermore, the first example of direct C-H alkynylation of carbazoles at the C1 position is also achieved. More importantly, the resulting product can be readily transformed into C7-alkynylated indoles, further widening the C-7 derivatization of indoles and highlighting the synthetic utility of this methodology.