Relationship between regional cardiac hyperinnervation and ventricular arrhythmia
Relationship between regional cardiac hyperinnervation and ventricular arrhythmia
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DOI：
10.1161/01.cir.101.16.1960
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发表时间：
2000-04-25
期刊：
影响因子：
37.8
通讯作者：
Chen, LS
中科院分区：
文献类型：
--
作者：
Cao, JM;Fishbein, MC;Chen, LS
背景-已知交感神经活动在室性心律失常发生中很重要，但关于心脏交感神经的分布与人类自发性室性心律失常发生之间关系的信息很少。方法和结果-我们研究了 53 个移植受者的原生心脏、5 个死于非心脏原因的患者尸检时获得的心脏以及 7 个从心室起源手术切除的心室组织。心动过速。回顾病史以确定是否存在（1A 组）或不存在（1B 组）自发性室性心律失常。对S100蛋白、神经丝蛋白、酪氨酸羟化酶和蛋白基因产物9.5进行免疫细胞化学染色，以研究交感神经的分布和密度。平均左心室射血分数为0.22+/-0.07。共有 30 名患者记录有室性心律失常，包括室性心动过速和心源性猝死。在所有 30 颗心脏中，在患病心肌和血管周围都观察到交感神经的区域性增加。 1A组患者的神经纤维密度（总神经数19.6+/-11.2/mm(2)，总神经长度3.3+/-3.0 mm/mm(2)）显着高于1B组患者（总神经数13.5+/-6.1/mm(2)，总神经长度2.0+/-1.1 mm/mm(2)，P
Background-Sympathetic nerve activity is known to be important in ventricular arrhythmogenesis, but there is little information on the relation between the distribution of cardiac sympathetic nerves and the occurrence of spontaneous ventricular arrhythmias in humans.Methods and Results-We studied 53 native hearts of transplant recipients, 5 hearts obtained at autopsy of patients who died of noncardiac causes, and 7 ventricular tissues that had been surgically resected from the origin of ventricular tachycardia. The history was reviewed to determine the presence (group 1A) or absence (group 1B) of spontaneous ventricular arrhythmias. Immunocytochemical staining for S100 protein, neurofilament protein, tyrosine hydroxylase, and protein gene product 9.5 was performed to study the distribution and the density of sympathetic nerves. The average left ventricular ejection fraction was 0.22+/-0.07. A total of 30 patients had documented ventricular arrhythmias, including ventricular tachycardia and sudden cardiac death. A regional increase in sympathetic nerves was observed around the diseased myocardium and blood vessels in all 30 hearts. The density of nerve fibers as determined morphometrically was significantly higher in group 1A patients (total nerve number 19.6+/-11.2/mm(2), total nerve length 3.3+/-3.0 mm/mm(2)) than in group 1B patients (total nerve number 13.5+/-6.1/mm(2) total nerve length 2.0+/-1.1 mm/mm(2), P