Impact of human immunodeficiency virus, malaria, and tuberculosis on adverse pregnancy outcomes in the United States
Impact of human immunodeficiency virus, malaria, and tuberculosis on adverse pregnancy outcomes in the United States
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DOI：
10.1038/s41372-019-0512-9
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发表时间：
2020-02-01
影响因子：
2.9
通讯作者：
Amdur, Richard L.
中科院分区：
文献类型：
--
作者：
Ahmadzia, Homa K.;Khorrami, Najma;Amdur, Richard L.
目的比较美国HIV、结核病和疟疾感染患者与未感染患者的不良妊娠结局发生率。研究设计在这项回顾性队列研究中，使用1998-2000年和2009-2011年期间导致分娩的妊娠住院情况确定了24，149，664例单胎活产的全国代表性样本。评价母儿结局。结果两个时期共发现HIV感染者7204例，结核病感染者1450例，疟疾感染者296例，感染者的平均年龄为28.3岁。在这两个时间段内，艾滋病毒感染组比对照组更有可能发生几乎所有不良妊娠结局。2009-2011年HIV组比1998-2000年HIV组更有可能接受剖宫产[1959 vs 1649，p < 0.0001]。结论在感染艾滋病毒、疟疾或结核病的孕妇中，感染艾滋病毒的孕妇比未感染的孕妇更有可能经历几种不良妊娠结局。
Objective To compare rates of adverse pregnancy outcomes for HIV, tuberculosis, and malaria-infected patients in the United States with those of uninfected patients. Study design A nationally representative sample of 24,149,664 singleton live births were identified using pregnancy hospitalizations that resulted in delivery between 1998-2000 and 2009-2011 in this retrospective cohort study. Maternal and fetal outcomes were evaluated. Results There were 7204 HIV cases, 1450 TB cases, and 296 malaria cases over the two time periods, and the average age of infected subjects was 28.3. The HIV group was more likely to have almost all adverse pregnancy outcomes than the control group in both time periods. The 2009-2011 HIV group was more likely to undergo cesarean delivery than the 1998-2000 HIV group [1959 versus 1649, p < 0.0001]. Conclusion Out of pregnant women infected with HIV, malaria, or tuberculosis, those infected with HIV are more likely to experience several adverse pregnancy outcomes than uninfected women.