The role of the blood-brain barrier Na-K-2Cl cotransporter in stroke.
The role of the blood-brain barrier Na-K-2Cl cotransporter in stroke.
复制标题
血脑屏障 Na-K-2Cl 协同转运蛋白在中风中的作用。
DOI：
10.1007/0-387-23752-6_6
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发表时间：
2004
影响因子：
--
通讯作者：
Anderson,StevenE
中科院分区：
文献类型：
--
作者：
O'Donnell,MarthaE;Lam,TinaI;Tran,Lien;Anderson,StevenE
该实验室和其他实验室的研究表明，BBB 内皮细胞中存在的 Na-K-2Cl 协同转运蛋白受到脑缺血期间存在的因素的刺激。此外，我们的原位研究表明，协同转运蛋白主要存在于管腔 BBB 膜中。这与管腔协同转运蛋白与管腔内 Na/K ATP 酶共同作用将 NaCl 分泌到大脑中的假设是一致的，在中风期间，BBB 协同转运蛋白活性增加，使得屏障将 NaCl 和水过度分泌到大脑中，促进细胞毒性水肿的形成。我们的体内 MCAO 中风研究为 BBB 协同转运蛋白在脑水肿形成中的作用提供了进一步的支持。总的来说，这些发现表明 BBB Na-K-2Cl 协同转运蛋白确实在很大程度上促进了中风中脑水肿的形成。
Studies from this and other laboratories have shown that the Na-K-2Cl cotransporter is present in BBB endothelial cells is stimulated by factors present during cerebral ischemia. Further, ourin situstudies have shown that the cotransporter resides predominantly in the luminal BBB membrane. This is consistent with the hypothesis that a luminal cotransporter works with abluminal Na/K ATPase to secrete NaCl into the brain, and during stroke, BBB cotransporter activity is increased such that the barrier hypersecretes NaCl and water into the brain, facilitating cytotoxic edema formation. Ourin vivoMCAO stroke studies provide further support for a role of the BBB cotransporter in cerebral ede-ma formation. Collectively, these findings suggest that the BBB Na-K- 2Cl cotransporter does indeed substantially contribute to cerebral edema formation in stroke.