Effects of usual nutrient intake and vitamin D status on markers of bone turnover in Swiss adolescents
Effects of usual nutrient intake and vitamin D status on markers of bone turnover in Swiss adolescents
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DOI：
10.1038/sj.ejcn.1601959
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发表时间：
2004-09-01
影响因子：
4.7
通讯作者：
Barclay, DV
中科院分区：
文献类型：
--
作者：
Ginty, F;Cavadini, C;Barclay, DV
目的：评估营养摄入和维生素D状况对I型胶原蛋白形成和降解的标志物在青春期的男孩和女孩的影响。设计：横断面研究。设置：沃州，西Switzerland.Subjects：共92名男孩和104名女孩，年龄11-16岁。收集身高、体重、青春期状态（坦纳分期自我评估）、营养摄入（3天膳食记录）和空腹血清25-羟基维生素D（25 OHD）浓度、胶原形成标志物（P1 NP）和胶原降解标志物（血清C-末端肽：S-CTX）等数据。在检查的营养物质中，只有钙磷比（Ca/P）与男孩的P1 NP呈正相关，在青春期状态调整后。男孩在每个坦纳期的25 OHD均显著降低。总的来说，15%的男孩和17%的女孩被确定为维生素D不足（血清25 OHD
Objective: To evaluate the effects of nutrient intake and vitamin D status on markers of type I collagen formation and degradation in adolescent boys and girls.Design: Cross-sectional study.Setting: Canton of Vaud, West Switzerland.Subjects: A total of 92 boys and 104 girls, aged 11-16 y. Data were collected on height, weight, pubertal status (self-assessment of Tanner stage), nutrient intake (3-day dietary record) and fasting serum concentration of 25-hydroxyvitamin D (25OHD), and markers of collagen formation (P1NP) and degradation ( serum C-terminal telopeptides: S-CTX).Results: Tanner stage was a significant determinant of P1NP in boys and girls and S-CTX in girls. Of the nutrients examined, only the ratio of calcium to phosphorus (Ca/P) was positively associated with P1NP in boys, after adjustment for pubertal status. 25OHD decreased significantly at each Tanner stage in boys. Overall, 15% of boys and 17% of girls were identified as being vitamin D insufficient (serum 25OHD