Multiple serotonin receptors: clinical and experimental aspects.
Multiple serotonin receptors: clinical and experimental aspects.
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DOI：
10.3109/10401239409148985
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发表时间：
1994-06-01
期刊：
影响因子：
--
通讯作者：
Roth, B L
中科院分区：
文献类型：
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作者：
Roth, B L
血清素（5-羟色胺; 5-HT）参与了大量的心理生理过程，包括睡眠、食欲、情绪、攻击性、感知、记忆和焦虑的调节。为了介导这一系列的生理过程，至少有14种不同的5-HT受体已经进化，它们被分为七个主要的家族。毫不奇怪，5-HT受体活性的改变已被证明发生在许多精神疾病中，包括焦虑症、抑郁症、进食障碍、精神分裂症、人格障碍和许多药物诱导的精神病状态。此外，已经开发了许多有效的精神药理学药物，用于治疗精神分裂症和焦虑症等多种疾病，这些药物可以特异性地改变脑中5-羟色胺的水平，也可以与5-HT受体亚型结合。这篇综述文章总结了在新兴领域的5-羟色胺受体药理学的最新进展，并将这些信息整合到一个连贯的角度对临床精神病学的重要性，β-羟色胺能药物。
Serotonin (5-hydroxytryptamine; 5-HT) has been implicated in a large number of psychophysiologic processes including the regulation of sleep, appetite, mood, aggression, perception, memory, and anxiety. To mediate this large array of physiologic processes, at least 14 separate 5-HT receptors have evolved, which are divided into seven main families. Not surprisingly, alterations of 5-HT receptor activity have been shown to occur in many psychiatric diseases including anxiety, depression, eating disorders, schizophrenia, personality disorders, and many drug-induced psychotic states. Additionally, a number of effective psychopharmacologic agents for diseases as diverse as schizophrenia and anxiety have been developed which either specifically alter brain levels of serotonin or bind to 5-HT receptor subtypes. This review article summarizes recent advances in the burgeoning field of serotonin receptor pharmacology and integrates this information into a coherent perspective on the importance of serotonergic agents for clinical psychiatry.