Reduced circulating levels of TWEAK are associated with Gestational Diabetes Mellitus
Reduced circulating levels of TWEAK are associated with Gestational Diabetes Mellitus
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DOI：
10.1111/eci.12375
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发表时间：
2015-01-01
影响因子：
5.5
通讯作者：
Megia, Ana
中科院分区：
文献类型：
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作者：
Simon-Muela, Inmaculada;Llaurado, Gemma;Megia, Ana
为探讨妊娠期肿瘤坏死因子样弱凋亡诱导因子（TWEAK）及其清道夫受体CD 163介导的炎症轴及其对正常妊娠和妊娠期糖尿病（GDM）患者胰岛素敏感性的影响，对137例单胎妊娠妇女（糖耐量正常组71例，GDM组66例）进行了研究。通过口服葡萄糖耐量试验评估糖代谢。在妊娠晚期早期，在招募时抽取母体血液，测定可溶性TWEAK（sTWEAK）和CD 163（sCD 163）的血清浓度以及胰岛素抵抗（HOMA-IR指数）。子代的体重和身高在birth.ResultsWomen与GDM有较低的循环sTWEAK浓度比对照NGT组（2378（1921-3010）pg/mL vs. 2772（2064-3557）pg/mL; P=0013）。sTWEAK与GDM（r=-0212; P=0013）、HOMA-IR指数（r=-0197; P=0021）和新生儿体重指数（r=-0196; P=0025）呈负相关，而与HDL胆固醇呈正相关（r=0283; P=0001）。多元回归分析显示，sTWEAK浓度是胰岛素抵抗的主要预测因子之一，沿着有BMI、甘油三酯和低浓度HDL胆固醇（R-2=0486; P
BackgroundTo evaluate the inflammatory axis mediated by tumour necrosis factor-like weak inducer of apoptosis (TWEAK) and its scavenger receptor CD163 during pregnancy and their influence on insulin sensitivity in normal pregnancy and in gestational diabetes mellitus (GDM).Materials and methodsOne hundred and thirty seven women with one singleton pregnancy, 71 with normal glucose tolerance (NGT) and 66 with GDM were studied. Glucose metabolism was assessed by oral glucose tolerance test. Serum concentrations of soluble TWEAK (sTWEAK) and CD163 (sCD163) and insulin resistance (HOMA-IR index) were determined in maternal blood drawn at recruitment, in the early third trimester. Offspring weight and height were assessed at birth.ResultsWomen with GDM had lower circulating sTWEAK concentrations than control NGT group (2378 (1921-3010) pg/mL vs. 2772 (2064-3557) pg/mL; P=0013). sTWEAK was negatively associated with the presence of GDM (r=-0212; P=0013), HOMA-IR index (r=-0197; P=0021) and ponderal index of the newborn (r=-0196; P=0025), but positively with HDL cholesterol (r=0283; P=0001). In multiple regression analysis, sTWEAK concentration emerged as one of the main predictors of insulin resistance, along with BMI, triglycerides and low concentrations of HDL cholesterol (R-2=0486; P