Cardiac Arrhythmia Due to Epicardial Fat: Is It a Modifiable Risk?
Cardiac Arrhythmia Due to Epicardial Fat: Is It a Modifiable Risk?
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心外膜脂肪引起的心律失常：是否是可改变的风险？
DOI：
10.1007/s12170-017-0547-4
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发表时间：
2017
影响因子：
1.9
通讯作者：
Yasuo Okumura
中科院分区：
文献类型：
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作者：
武井洋介;森敬善;前田敦雄;明石嘉浩;阿古潤哉;伊苅裕二;海老名俊明;佐藤直樹;並木淳郎;福井和樹;道下一朗;木村一雄;鈴木洋;Yasuo Okumura
肥胖和代谢综合征是心律失常，尤其是心房颤动（AF）风险的可改变的决定因素之一。内脏脂肪与肥胖或代谢综合征之间的密切联系已得到证实。最近，许多临床研究关注心外膜脂肪组织（EAT），作为内脏脂肪和心律失常，特别是房颤。越来越多的数据表明，EAT与房颤的发病率和严重程度有关。一些实验研究表明，EAT对心血管系统有生化影响，包括胰岛素抵抗、动脉粥样硬化、高血压、动脉僵硬、冠状动脉血流储备受损、心脏缺血、心脏缺血等。游离脂肪酸摄取率高，肾上腺素能活性高，局部和全身炎症高。由于与AF和EAT相关的多种因素，确切的潜在机制尚不清楚。此外，EAT与室性心动过速之间的关系尚不清楚。本文综述了EAT在心房颤动、室性心动过速等心律失常发病机制中的作用，并探讨了EAT是否可能是心律失常的一个可改变的危险因素。
Purpose of ReviewObesity and metabolic syndrome are one of the modifiable determinants for the risk of cardiac arrhythmias, especially atrial fibrillation (AF). A strong association between visceral fat and obesity or metabolic syndrome has been established.Recent FindingsRecently, much clinical interest has been focused on epicardial adipose tissue (EAT), as visceral fat and cardiac arrhythmias, especially in AF. Increasing data suggests that EAT is associated with the incidence and severity of AF. Several experimental studies have shown that EAT exerts biochemical effects on the cardiovascular system, including insulin resistance, atherosclerosis, hypertension, arterial stiffness, an impaired coronary flow reserve, and a high rate of free fatty acid uptake, beta-adrenergic activity, and local and systemic inflammation. Due to multiple factors associated with AF and EAT, the exact underlying mechanism remains unknown. In addition, the association between EAT and ventricular tachyarrhythmias remains unclear.SummaryIn the present paper, we reviewed the role that EAT plays in the pathogenesis of cardiac arrhythmias such as AF and ventricular tachyarrhythmias and explored whether EAT could be a modifiable risk factor for cardiac arrhythmias.