Oxytocin, motherhood and bonding
Oxytocin, motherhood and bonding
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DOI：
10.1111/j.1469-445x.2000.tb00014.x
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发表时间：
2000-03-01
影响因子：
2.7
通讯作者：
Kendrick, KM
中科院分区：
文献类型：
--
作者：
Kendrick, KM
大脑中肽激素催产素的释放已被证明会影响母性，性和社会联系行为，尽管存在一些物种差异。本文综述了催产素和催产素受体在脑中的分布，以及它们的表达，肽在脑中的释放及其行为作用的影响因素。催产素如何可能会采取行动，以改变产妇和社会性行为的模型提出，最初涉及激活催产素神经元在一个单一的大脑网站，下丘脑室旁核（PVN），阴道和宫颈刺激。这导致PVN及其末端投射区域中肽的协调释放长达1小时，这主要通过调节经典递质系统促进不同的行为成分。
Release of the peptide hormone oxytocin in the brain has been shown to influence both maternal, sexual and social bonding behaviours although there are a number of species differences. This review summarizes findings on the distributions of oxytocin and oxytocin receptors in the brain, together with factors governing their expression, release of the peptide in the brain and its behavioural actions. A model of how oxytocin may act to alter maternal and socio-sexual behaviours is proposed which initially involves activation of oxytocin neurones in a single brain site, the paraventricular nucleus of the hypothalamus (PVN), following vaginal and cervical stimulation. This causes a co-ordinated release of the peptide in the PVN and its terminal projection regions for up to 1 h and this promotes different behavioural components, primarily through modulation of classical transmitter systems.