Fetal ocular measurements by three-dimensional ultrasound
Fetal ocular measurements by three-dimensional ultrasound
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DOI：
10.1016/j.jaapos.2013.02.006
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发表时间：
2013-06-01
期刊：
影响因子：
1.6
通讯作者：
Moron, Antonio Fernandes
中科院分区：
文献类型：
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作者：
Bojikian, Karine Duarte;de Moura, Christiane Rohm;Moron, Antonio Fernandes
目的应用虚拟器官计算机辅助分析（VOCAL）方法建立三维超声正常胎儿眼体积（FEV）的参考范围，并比较手动和球体两种示迹模式的再现性。方法：这项前瞻性、纵向观察性研究在单中心进行，涉及37例17 - 40周胎龄胎儿的71只眼。仅包括无胎儿生长受限、糖尿病、高血压或重大胎儿畸形的妊娠。胎儿的眼睛测量是在常规超声检查中由一个观察者获得的。结果平均FEV手动模式从17-18周时的309.5 +/- 80.1 mm(3)到39-40周时的2552.1 +/- 384.9 mm(3)。平均FEV球体模式从17-18周的394.8 +/- 71.8 mm(3)到39-40周的2682.1 +/- 343.4 mm(3)不等。相关性从R-2 = 0.85（横径和胎龄）到R-2 = 0.91 （FEV球体模式和胎龄）。所有相关性均有统计学意义（P < 0.001）。虽然高度相关（R-2 = 0.97, P < 0.001），但手工测量和球体测量之间存在固定偏差。这些测量结果之间的一致性没有比例偏差（P = 0.89）。结论本研究为voice法手工模式下的FEV提供了参考值。这些正常生长参数可用于胎儿眼睛的常规超声评估，特别是在有影响眼部生长的遗传疾病风险的家庭，如先天性青光眼。
PURPOSE To establish a reference range for normal fetal eye volume (FEV) by three-dimensional ultrasound using Virtual Organ Computer-aided AnaLysis (VOCAL) method and compare the reproducibility between the two trace modes (manual and sphere).METHODS This prospective, longitudinal observational study was performed at a single center and involved 71 eyes of 37 fetuses between 17 and 40 weeks of gestational age. Only pregnancies without fetal growth restriction, diabetes mellitus, hypertension, or major fetal malformation were included. Fetuses eye measurements were obtained by a single observer during routine ultrasonographic examination.RESULTS Mean FEV manual mode ranged from 309.5 +/- 80.1 mm(3) at 17-18 weeks to 2552.1 +/- 384.9 mm(3) at 39-40 weeks. Mean FEV sphere mode ranged from 394.8 +/- 71.8 mm(3) at 17-18 weeks to 2682.1 +/- 343.4 mm(3) at 39-40 weeks. Correlations ranged from R-2 = 0.85 (transversal diameter and gestational age) to R-2 = 0.91 (FEV sphere mode and gestational age). All correlations were statistically significant (P < 0.001). Although highly correlated (R-2 = 0.97, P < 0.001), there was a fixed bias between manual and sphere measurements. The agreement between these measurements showed no proportional bias (P = 0.89).CONCLUSIONS The present study establishes reference values for FEV using the VOCAL method manual mode. These normal growth parameters can be used in routine ultrasound assessment of the fetal eye, especially in families at risk of genetic diseases that affect ocular growth, such as congenital glaucoma.