Difference-Frequency Ultrasound Imaging With Non-Linear Contrast.
Difference-Frequency Ultrasound Imaging With Non-Linear Contrast.
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DOI：
10.1109/tmi.2019.2957280
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发表时间：
2020-05
影响因子：
10.6
通讯作者：
Chu S
中科院分区：
文献类型：
--
作者：
Li Y;Polyak D;Johnson E;Yecies D;Shevidi S;de la Zerda A;Gephart MH;Chu S
传统的超声成像是基于密度和声速不均匀引起的声音散射，通常用于医学上区分与正常组织相比的病理组织。在这里，我们展示了一种差频超声（dfUS）成像方法，该方法基于两个非共线传播并在空间和时间上相交的声脉冲的相互作用。dfUS信号主要来自二阶非线性系数，这是一种不同于线性和谐波超声成像的对比机制。独特的对比机制允许dfUS成像在鲑鱼和猪肾组织的常规超声图像中无法识别的解剖特征。此外，dfUS可增强植入小鼠大脑的胶质母细胞瘤肿瘤的造影剂，显示其改善医学诊断的潜力。讨论了实时系统的进展。
Conventional ultrasound imaging is based on the scattering of sound from inhomogeneities in the density and the speed of sound and is often used in medicine to resolve pathologic compared to normal tissue. Here we demonstrate a difference-frequency ultrasound (dfUS) imaging method that is based on the interaction of two sound pulses that propagate non-collinearly and intersect in space and time. The dfUS signal arises primarily from the second-order non-linear coefficient, a contrast mechanism that differs from linear and harmonic US imaging. The distinct contrast mechanism allows dfUS to image anatomic features that are not identifiable in conventional US images of salmon and pig kidney tissue. Further, dfUS produces enhanced contrast of glioblastoma tumor implanted in the mouse brain, revealing its potential for improving medical diagnosis. Progress towards a real-time system is discussed.