Synthesis of Eel-Calcitonin and [Asu1,7]-Eel-Calcitonin: Contribution of the disulfide bond to the hormonal activity
Synthesis of Eel-Calcitonin and [Asu1,7]-Eel-Calcitonin: Contribution of the disulfide bond to the hormonal activity
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Eel-降钙素和 [Asu1,7]-Eel-降钙素的合成：二硫键对激素活性的贡献
DOI：
10.1007/bf01927568
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发表时间：
1976
期刊：
影响因子：
--
通讯作者：
M. Otani
中科院分区：
文献类型：
--
作者：
T. Morikawa;E. Munekata;S. Sakakibara;T. Noda;M. Otani
采用传统的溶液法合成了鳗鱼降钙素及其[Asu 1，7]-类似物-脱氨基二卡巴类似物。天然型产品显示出4300 MRC U/mg的降血钙效力，这与从鳗鱼中分离的天然激素相当。Asu类似物的激素活性也高达3400 MRC U/mg。
Eel-calcitonin and its [Asu1,7]-analog, deamino-dicarba-analog, were synthesized by the conventional solution method. The natural-type product showed 4300 MRC U/mg in the hypocalcemic potency which was comparable to that of the natural hormone isolated from eel. Hormonal activity of the Asu-analog was also as high as 3400 MRC U/mg.