Antagonistic pleiotropy may help population-level selection in maintaining genetic polymorphism for transmission rate in a model phytopathogenic fungus
Antagonistic pleiotropy may help population-level selection in maintaining genetic polymorphism for transmission rate in a model phytopathogenic fungus
复制标题
拮抗多效性可能有助于群体水平选择，以维持模型植物病原真菌传播率的遗传多态性
作者：
A. Tellier;L. M. Villaréal;T. Giraud
理论上已经证明，保持多效性基因座的多态并对适应度成分产生拮抗作用的条件是相当严格的。在这里，我们使用集合种群模型来研究拮抗多效性是否有助于维持植物病原真菌小菜蛾中常见有害等位基因的多态性。这种真菌引起石竹科的花药黑穗病。以前的模型表明，由于创始人效应和群体水平的选择，当四分体内自交(同一减数分裂产物之间的交配)较高时，与性别相关的有害等位基因可以在集合种群结构下保持。在这里，我们在集合种群模型中增加了两种类型的多向性优势。携带与性别相关的有害等位基因的菌株的竞争优势不利于它们的维持，因为竞争情况太少了。相反，较高的产孢量确实有利于有害等位基因在较低的四分体交配率下保持，对产孢量有很大的优势。这些结果表明，拮抗多效性可能与其他选择力量相结合，促进遗传变异的持久性。
It has been shown theoretically that the conditions for the maintenance of polymorphism at pleiotropic loci with antagonistic effects on fitness components are rather restrictive. Here, we use a metapopulation model to investigate whether antagonistic pleiotropy could help maintain polymorphism involving common deleterious alleles in the phytopathogenic fungus Microbotryum violaceum. This fungus causes anther smut disease of the Caryophyllaceae. A previous model has shown that the sex-linked deleterious alleles can be maintained under a metapopulation structure, when intra-tetrad selfing (mating between products of the same meiosis) is high, due to founder effects and selection at the population level. Here, we add two types of pleiotropic advantages to the metapopulation model. A competitive advantage for strains carrying the sex-linked deleterious alleles did not facilitate their maintenance because competitive situations were too rare. In contrast, higher spore production did facilitate the maintenance of the deleterious alleles at low intra-tetrad mating rates and with a large advantage for spore production. These results show that antagonistic pleiotropy may promote the persistence of genetic variation, in combination with other selective forces.
果蝇寿命延长的遗传学。
DOI：
10.1002/bies.950110505
发表时间：
1989
期刊：
BioEssays : news and reviews in molecular, cellular and developmental biology
影响因子：
--
作者：
Rose,MR
通讯作者：
Rose,MR