PIVMECILLINAM IN TREATMENT OF SALMONELLA CARRIERS
PIVMECILLINAM IN TREATMENT OF SALMONELLA CARRIERS
复制标题
DOI：
10.1093/jac/3.suppl_b.103
复制
发表时间：
1977-01-01
影响因子：
5.2
通讯作者：
JONSSON, M
中科院分区：
文献类型：
--
作者：
JONSSON, M
十二名慢性沙门氏菌携带者接受匹美西林治疗。 12 人中有 8 人被治愈。其中1名治愈患者在治疗期间接受了胆囊切除术，2名患者在第二次大剂量治疗联合胆囊切除术后才治愈。在 4 名未通过抗生素治疗治愈的携带者中，出现了耐药沙门氏菌，尽管只有 1 例对 mecil linam 具有耐药性。抗生素耐药性和R因子携带菌株出现的频率与施用氨苄青霉素后获得的频率相似。发现了质粒介导的匹美西林耐药性。
Twelve chronicSalmonellacarriers were treated with pivmecillinam. Eight out of 12 were cured. One of the cured patients underwent cholecystectomy during the treatment period and 2 were only cured when a second high dose treatment was combined with cholecystectomy. In the 4 carriers not cured by antibiotic therapy resistantSalmonellaemerged, though in only one case were these resistant to mecil linam. The frequency of the emergence of antibiotic resistance and ofR-factor carrying strains was similar to that obtained after administration of ampicillin. Plasmid mediated resistance against pivmecillinam was found.