Selective loss of hippocampal granule cells in the mature rat brain after adrenalectomy.
Selective loss of hippocampal granule cells in the mature rat brain after adrenalectomy.
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DOI：
10.1126/science.2911756
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发表时间：
1989-01
期刊：
影响因子：
56.9
通讯作者：
R. S. Sloviter;G. Valiquette;G. Abrams;Edward C. Ronk;Anne L. Sollas;L. Paul;S. Neubort
中科院分区：
文献类型：
--
作者：
R. S. Sloviter;G. Valiquette;G. Abrams;Edward C. Ronk;Anne L. Sollas;L. Paul;S. Neubort
成年雄性大鼠肾上腺切除后3~4个月，海马区颗粒细胞几乎完全消失。海马神经元尼氏染色和免疫细胞化学染色显示，颗粒细胞的丢失是选择性的，未见明显的海马锥体细胞或γ-氨基丁酸(GABA)、生长抑素、神经肽Y-、钙结合蛋白或含小白蛋白的中间神经元的丢失。去肾上腺动物的海马CA1区锥体细胞对传入刺激表现出正常的电生理反应，而在齿状回诱发的反应严重减弱。皮质酮替代可防止肾上腺切除所致的颗粒细胞丢失和减弱的生理反应。因此，肾上腺在维持正常成人大脑的结构完整性方面起着作用。
Adrenalectomy of adult male rats resulted in a nearly complete loss of hippocampal granule cells 3 to 4 months after surgery. Nissl and immunocytochemical staining of hippocampal neurons revealed that the granule cell loss was selective; there was no apparent loss of hippocampal pyramidal cells or of gamma-amino butyric acid (GABA)-, somatostatin-, neuropeptide Y-, calcium binding protein-, or parvalbumin-containing hippocampal interneurons. The hippocampal CA1 pyramidal cells of adrenalectomized animals exhibited normal electrophysiological responses to afferent stimulation, whereas responses evoked in the dentate gyrus were severely attenuated. Corticosterone replacement prevented both the adrenalectomy-induced granule cell loss and the attenuated physiological response. Thus, the adrenal glands play a role in maintaining the structural integrity of the normal adult brain.