Gene localisation of the PGM1 enzyme system and the Duffy blood groups on chromosome No. 1 by means of a new fragile site at 1p31
Gene localisation of the PGM1 enzyme system and the Duffy blood groups on chromosome No. 1 by means of a new fragile site at 1p31
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通过 1p31 处的新脆弱位点对 1 号染色体上的 PGM1 酶系统和达菲血型进行基因定位
DOI：
10.1007/bf00273078
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发表时间：
1985
期刊：
影响因子：
5.3
通讯作者：
W. Schnedl
中科院分区：
文献类型：
--
作者：
J. Herbich;J. Szilvássy;W. Schnedl
在常规亲子鉴定过程中，PGM1 酶系统（母亲 PGM11，孩子 PGM12）和 Duffy 系统（母亲 Fy(a-b+)，孩子 Fy(a+b-)）建议明显的母亲排除。为了澄清这些发现，进行了染色体分析和人类学调查。孩子出生后被误认的可能性就可以消除了。对孩子的染色体分析显示，1 号染色体 1p31 处有一个脆弱位点，该位置应该携带 PGM1 和 Duffy 基因座。尽管孩子的父亲未知，但由于结构畸变与被认为位于相关染色体区域的母体 PGM1 和 Duffy 等位基因的缺失表达相一致，该脆弱位点不太可能是父系起源。因此，1p31 上的 PGM1 和 Duffy 基因座的定位似乎是以一种不寻常的方式实现的。这两个基因座似乎紧密相连。
During routine paternity testing an apparent maternal exclusion was suggested by the PGM1enzyme system (mother PGM11, child PGM12) and by the Duffy system (mother Fy(a-b+), child Fy(a+b-)). To clarify these findings chromosomal analyses and anthropological investigations were carried out. The possibility that the child had been mistakenly identified after birth could be eliminated. Chromosome analysis of the child showed a fragile site on one chromosome No. 1 at 1p31, a position supposed to carry the PGM1and the Duffy loci. Although the father of the child is unknown, paternal origin of the fragile site is unlikely on account of the coincidence of the structural aberration with the missing expression of the maternal PGM1and Duffy alleles thought to be located at the chromosome region involved. Thus localisation of the PGM1and Duffy loci on 1p31 seems to have been achieved in an unusual way. The two loci appear to be closely linked.