Visual receptive field properties of neurons in the superficial superior colliculus of the mouse.
Visual receptive field properties of neurons in the superficial superior colliculus of the mouse.
复制标题
DOI：
10.1523/jneurosci.3305-10.2010
复制
发表时间：
2010-12-08
期刊：
影响因子：
--
通讯作者：
Cang J
中科院分区：
文献类型：
--
作者：
Wang L;Sarnaik R;Rangarajan K;Liu X;Cang J
由于可用的遗传工具，小鼠是研究视觉系统功能和发育的有希望的模型。然而，视觉感受野特性的定量分析尚未进行小鼠上级丘（SC），尽管它的重要性，在小鼠的视觉和发育研究的有用性。我们已经从麻醉的C57/B16小鼠的SC的浅层进行了单单位细胞外记录。我们首先映射感受野与闪光点刺激，并表明，大多数SC神经元有空间重叠的ON和OFF子字段。与漂移的正弦光栅，然后，我们确定个别SC神经元的调谐特性，包括刺激方向和取向的选择性，空间频率调谐，时间频率调谐，响应线性，和大小偏好。广泛的感受野的大小和选择性，观察整个人口和各种亚型的SC神经元形态学鉴定。特别是，在小鼠SC中发现了方向选择性反应，并且它们不受皮质损伤或长期视觉剥夺的影响。另一方面，SC神经元的ON/OFF特性和空间频率调谐受皮层输入的影响，并且需要在发育期间的视觉经验。总之，我们的研究结果提供了必要的信息，为今后的调查功能发展的上级丘。
The mouse is a promising model in the study of visual system function and development because of available genetic tools. However, a quantitative analysis of visual receptive field properties had not been performed in the mouse superior colliculus (SC) despite its importance in mouse vision and its usefulness in developmental studies. We have made single-unit extracellular recordings from superficial layers of the SC in urethane-anesthetized C57/Bl6 mice. We first map receptive fields with flashing spot stimuli and show that most SC neurons have spatially overlapped ON and OFF subfields. With drifting sinusoidal gratings, we then determine the tuning properties of individual SC neurons, including selectivity for stimulus direction and orientation, spatial frequency tuning, temporal frequency tuning, response linearity, and size preference. A wide range of receptive field sizes and selectivity are observed across the population and in various subtypes of SC neurons identified morphologically. In particular, orientation selective responses are discovered in the mouse SC, and they are not affected by cortical lesion or long-term visual deprivation. On the other hand, ON/OFF characteristics and spatial frequency tuning of SC neurons are influenced by cortical inputs and require visual experience during development. Together, our results provide essential information for future investigations on the functional development of the superior colliculus.