Cardiac Amyloid Imaging with 18F-Florbetaben PET: A Pilot Study
Cardiac Amyloid Imaging with 18F-Florbetaben PET: A Pilot Study
复制标题
DOI：
10.2967/jnumed.115.169870
复制
发表时间：
2016-11-01
影响因子：
9.3
通讯作者：
Ng, Arnold C. T.
中科院分区：
文献类型：
--
作者：
Law, W. Phillip;Wang, William Y. S.;Ng, Arnold C. T.
我们的目的是确定F-18-florbetaben PET诊断心脏淀粉样变性的可行性。研究方法：对14例患者进行了F-18-florbetaben PET：5例淀粉样轻链，5例淀粉样甲状腺素运载蛋白，4例高血压心脏病对照。使用左心室心肌和血池的SUV平均值以及目标与背景SUV比的计算，对F-18-氟贝他本活性进行定性和定量评估。心肌F-18-forbetaben保留也计算为放射性示踪剂注射后0和5 min以及15和20 min之间的平均心肌SUV变化百分比。采用二维斑点追踪超声心动图计算左室整体纵向应变和右室游离壁纵向应变。结果如下：淀粉样蛋白患者的靶向背景SUV比率和心肌F-18-forbetaben保留百分比高于高血压对照组。40%的临界值能够区分心脏淀粉样蛋白患者和高血压对照。心肌F-18-forbetaben保留百分比是一个独立的决定因素，全球左心室纵向和右心室游离壁纵向应变通过一个反曲线关系。结论：F-18-florbetaben PET显像能准确鉴别心脏淀粉样变和高血压性心脏病。心肌F-18-florbetaben保留百分比是心脏淀粉样变性患者心肌功能障碍的独立决定因素。
Our aim was to determine the feasibility of F-18-florbetaben PET in diagnosing cardiac amyloidosis. Methods: F-18-florbetaben PET was performed on 14 patients: 5 amyloid light chain, 5 amyloid transthyretin, and 4 control with hypertensive heart disease. Qualitative and quantitative assessments of F-18-florbetaben activity were performed using the SUVmean of the left ventricular myocardium and blood pool and calculation of target-to-background SUV ratio. Myocardial F-18-forbetaben retention was also calculated as the percentage mean myocardial SUV change between 0 and 5 min and 15 and 20 min after radiotracer injection. Global left ventricular longitudinal and right ventricular free wall longitudinal strain were calculated using 2-dimensional speckle-tracking echocardiography. Results: Target-to-background SUV ratio and percentage myocardial F-18-forbetaben retention were higher in amyloid patients than in hypertensive controls. A cutoff of 40% was able to differentiate between cardiac amyloid patients and hypertensive controls. Percentage myocardial F-18-forbetaben retention was an independent determinant of both global left ventricular longitudinal and right ventricular free wall longitudinal strain via an inverse curve relationship. Conclusion: F-18-florbetaben PET imaging can accurately identify and differentiate between cardiac amyloidosis and hypertensive heart disease. Percentage myocardial F-18-florbetaben retention was an independent determinant of myocardial dysfunction in cardiac amyloidosis.