GENETIC AND PHYLOGENETIC VARIATION IN THE DIFFERENT MOLECULAR FORMS OF MAMMALIAN ERYTHROCYTE CARBONIC ANHYDRASES *
GENETIC AND PHYLOGENETIC VARIATION IN THE DIFFERENT MOLECULAR FORMS OF MAMMALIAN ERYTHROCYTE CARBONIC ANHYDRASES *
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哺乳动物红细胞碳酸酐酶不同分子形式的遗传和系统发育变异*
DOI：
10.1111/j.1749-6632.1968.tb11878.x
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发表时间：
1968
影响因子：
5.2
通讯作者：
T. Shows
中科院分区：
文献类型：
--
作者：
R. Tashian;D. Shreffler;T. Shows
已知哺乳动物红细胞具有一种或两种分子形式的碳酸酐酶（参见图1）。Tashian;' Armstrong et al.;' Duff and科尔曼; Nyman and Lin d ~ k o g ; ~ and Edsall，previous paper）.在本报告中，我们将比较一些遗传和化学方面的假定同源形式的红细胞碳酸酐酶从各种哺乳动物物种。这种类型的比较研究给了我们一个不寻常的机会来分析发生在两种酶分子中的变化，这两种酶分子很可能是由基因复制过程引起的（参见《生物化学》）。Nyman e ta l .”），并且从那时起就在相同或相似的细胞质环境中“进化”。如果这种复制发生在哺乳动物的进化过程中，那么甚至有可能确定其大致的系统发育位置;并且，通过这样做，确定两种分子中的哪一种代表原始形式。在本文中将酶形式称为碳酸酐酶I和I1（CA I和CA 11），它们分别与其他研究者使用的名称CA B和CA C相同。“^ 3
Mammalian erythrocytes are known to possess either one or two molecular forms of carbonic anhydrase (c f . Tashian;’ Armstrong et al.;’ Duff and Coleman; Nyman and L i n d ~ k o g ; ~ and Edsall, preceding paper). In the present report, we will compare some genetic and chemical aspects of the presumed homologous forms of red cell carbonic anhydrase from various mammalian species. This type of comparative study gives us an unusual opportunity to analyze the changes that have occurred in two enzyme molecules which have, in all probability, originated by a process of gene duplication (cf. Nyman e ta l .”) , and have been “evolving” since that time in the same, or a similar, cytoplasmic environment. If this duplication occurred during the evolution of mammals, it might even be possible to locate its approximate phylogenetic position; and, by so doing, determine which of the two molecules represents the original form. The enzyme forms will be referred to in this paper as carbonic anhydrases I and I1 (CA I and CA 11) which are identical to the designations CA B and CA C, respectively, used by other investigator^."^ 3