DNA Methylation in Skeletal Muscle Stem Cell Specification, Proliferation, and Differentiation.
DNA Methylation in Skeletal Muscle Stem Cell Specification, Proliferation, and Differentiation.
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DOI：
10.1155/2016/5725927
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发表时间：
2016
影响因子：
4.3
通讯作者：
Ryall JG
中科院分区：
文献类型：
--
作者：
Laker RC;Ryall JG
骨骼肌生物学中一个尚未解决且至关重要的问题是肌肉干细胞如何在肌肉发育过程中启动和调节遗传程序。表观遗传动力学对于生命早期的细胞发育和器官发生至关重要，并且越来越清楚的是，表观遗传重塑也可能与晚年发生的细胞适应有关。 CpG 二核苷酸对内胞嘧啶碱基的 DNA 甲基化是一种重要的表观遗传修饰，当位于启动子或增强子区域内时，它会降低基因表达。该领域的最新进展表明表观遗传调控对于骨骼肌干细胞的识别和随后的细胞发育至关重要。这篇综述总结了目前已知的骨骼肌干细胞如何通过 DNA 甲基化调节生肌程序，讨论了代谢在此过程中的新作用，并解决了成人骨骼肌响应身体活动的 DNA 甲基化动态。
An unresolved and critically important question in skeletal muscle biology is how muscle stem cells initiate and regulate the genetic program during muscle development. Epigenetic dynamics are essential for cellular development and organogenesis in early life and it is becoming increasingly clear that epigenetic remodeling may also be responsible for the cellular adaptations that occur in later life. DNA methylation of cytosine bases within CpG dinucleotide pairs is an important epigenetic modification that reduces gene expression when located within a promoter or enhancer region. Recent advances in the field suggest that epigenetic regulation is essential for skeletal muscle stem cell identity and subsequent cell development. This review summarizes what is currently known about how skeletal muscle stem cells regulate the myogenic program through DNA methylation, discusses a novel role for metabolism in this process, and addresses DNA methylation dynamics in adult skeletal muscle in response to physical activity.